Skill 26

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Penn Foster College *

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131

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Medicine

Date

Jan 9, 2024

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docx

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7

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Prescription Medications: Apoquel (Oclacitinib) Drug Class: Janus Kinase (JAK) Inhibitor Class Controlled Status: Not a controlled substance Therapeutic Effects: Control of pruritus associated with allergic dermatitis and control of atopic dermatitis Mechanisms of Action: Inhibits the function of pruritogenic cytokines and pro- inflammatory cytokines, as well as those involved that are dependent on JAK1 or JAK3 enzyme activity Contraindications: Not for dogs under 12 months, not for dogs with serious infections, not for use in breeding, pregnant, or lactating dogs Side Effects: Vomiting, lethargy, anorexia, diarrhea, elevated liver enzymes (Zoetis, 2020) Galliprant (Grapiprant) Drug Class: Piprant Class Controlled Status: Not a controlled substance Therapeutic Effects: Reduce acute and chronic pain and inflammation Mechanisms of Action: Non-COX inhibiting NSAID that specifically targets the EP4 receptor, and prostaglandin E2 which acts as a pro-inflammatory mediator of skin redness, edema, and pain Contraindications: Should not be used in dogs allergic to the drug, dogs younger than 9 months, dogs weighing less than 8 pounds, breeding, pregnant, or nursing dogs, or in dogs with severe heart disease
Side Effects: Vomiting, diarrhea, low appetite, blood or mucous in stool, and decreased blood protein levels (Gollakner, n.d.) Buprenex (Buprenorphine) Drug Class: Narcotic Analgesic Controlled Status: Schedule III Therapeutic Effects: Helps manage and dull pain, especially before, during, and after surgery Mechanisms of Action: Partial agonist of the mu receptor, weak kappa receptor antagonist and delta receptor agonist Contraindications: Not for pets with liver disease, respiratory depression, or those with a known sensitivity to opiates. Not for those taking MAOIs, opiate agonists or antagonists, protein bound drugs, naloxone, or pancuronium bromide Side Effects: Respiratory depression and sedation (Bourne, 2020) Theophylline Drug Class: Bronchodilator Controlled Status: Not a controlled substance Therapeutic Effects: Prevent and treat asthma, chronic bronchitis, emphysema, and other lung diseases by relaxing and opening air passages in the lungs, making it easier to breathe Mechanisms of Action: Relaxes the smooth muscles located in the brochial airways and pulmonary blood vessels
Contraindications: Should not be used in pets allergic to it, and used with caution in pets with severe heart disease, abnormal heart rhythms, seizures, stomach ulcers, hyperthyroidism, or kidney or liver disease Side Effects: CNS excitement, nausea, vomiting, and diarrhea (VCA Animal Hospitals, n.d.) Cephalexin Drug Class: Cephalosporin Antibiotic Controlled Status: Not a controlled substance Therapeutic Effects: Treat or prevent bacterial infections Mechanisms of Action: Inhibits bacterial cell wall synthesis, leading to breakdown and eventual cell death Contraindications: Not for use in pets with a known allergy to the drug; use caution in pregnant and nursing animals Side Effects: Lack of appetite, vomiting, and diarrhea (Gollakner, n.d.) Over the Counter Medications: Terramycin Drug Class: Tetracycline Antibiotic Controlled Status: Not a controlled substance Therapeutic Effects: Treat symptoms of bacterial infection Mechanisms of Action: Inhibits protein synthesis of gram-positive and -negative bacteria Contraindications: Not for use in pets with a known allergy to the drug; use caution in pets with liver or kidney disease
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