Review article
A Review on Management of Colo-rectal Cancer: Nano-technology
Qurat Ul Ain, Nabeela Shaheen, Sadia Tabassum,
Riphah Institute of Pharmaceutical Sciences (RIPS), Riphah International University, G 7/4, 7th Avenue, Islamabad, Pakistan.
Abstract:
Colorectal cancer is one of the fatal diseases of this era with quite higher incidence rate. Due to a high fatality rate, health organizations and researchers are continuously looking for new and better management options. In this strive, nanotechnology served as a major and novel treatment methodology with betterment and more optimum outcomes. Work is carried out with respect to colo-rectal malignancies where nano-particles are either used as diagnostic tools or they serve as treatment tools for targeted drug delivery to the tumor cells. This all leads to more specific and sensitive drug delivery to site of action thus minimizing the dose associated and non-specific drug delivery side-effects. The following review article will address such efforts and their impact to reduce disease burden, thus improving future prospects of the disease.
Keywords:
Nanotechnology Nano-particles Colo-rectal cancer Diagnosis Treatment Introduction:
Colo-rectal cancer is the 2nd leading cause of deaths in world [1] and is ranked 3rd in terms of cancer relate deaths in United States [2]. It is more common in developed countries than developing one [1] and so is called a disease of western
“The colon cancer vs. Crohn’s disease debate is generating a lot of interest in the medical community. Every year in the U.S., approximately 57,000 people die from colorectal cancer and 147,000 new cases are diagnosed”states Dr. Victor Marchione. Crohn's disease is a new disease that was introduced into today's society in 2015. 1.4 million Americans have Crohn’s disease or ulcerative colitis. Of those, about 700,000 have Crohn’s has been diagnosed in the years between 1992 and 2004 just from a doctor's visit. People have came up with different ways that we can help and prevent the disease such as Surgery, Conferences and “ KEY TO PROCESS “.
One of the many goals developed by the United States Government in its Healthy People 2020 campaign was to “reduce the number of new cancer cases, as well as the illness, disability, and death caused by cancer” (Healthy People 2020, 2016). This goal is further broken down by cancer types. The goals for colorectal cancer (CRC) is to reduce the 2007 baseline mortality rate of 17.1 deaths per 100,000 to 14.5 deaths per 100,000 and to increase the proportion of adults to receive colorectal cancer screening (CRCS) based on the most recent guidelines by the year 2020. The American Cancer Society (ACS,
In the United States (U.S.), colorectal cancer (CRC) is the second major cause of cancer associated deaths. During 2008-2012, per year incidence and mortality counts due to CRC were 42.4 and 15.5 per 100,000 men and women [2]. However, during 2008-2012 the incidence rate of CRC in AA population was 101.2 (16.89% higher) as compared to 84.1 of CA per 100,000 men and women. Moreover, the number of AA deaths associated with CRC was 47.5 (54.72% higher) in comparison with 30.7 CA deaths per 100,000 men and women [2]. CRC patients of AA
Colon cancer is cancer that impacts the rectum or colon, which is the large intestine, and sometimes doctors and scholars call it colorectal cancer (1).In the U.S studies showed that in 2006 there would be more than 145.000 of colon cancer cases, and the death from it would be 55.000(5).In the U.K also studies showed there are more than 28.000 cases, and the deaths are 17.000(6). Colon cancer is killer diseases, and develops slowly, so most people with colon cancer do not express any symptoms (2).The tumor begins as polyps in the colon for years then these polyps grow and turn to cancer(2).Moreover, colon cancer has several stages. The stage is an essential guide to how far the tumor has grown into the colon wall,
The American Cancer Society estimates that over 100,000 men and women living in the United States will be diagnosed with colon cancer in 2013. Statistically, cancers of the colon and rectum are often combined and referred to as colorectal cancer. This addition brings the total to over 140,000 affected individuals with over 50,000 of these diagnoses resulting in death (American cancer society, 2013). Globally, the impact of this disease reached over one million people in 2008 with over 600,000 deaths attributed to colorectal cancer (Dusek, Maluskova, & Musik, 2013).
used the distance from the anal verge to the lowest aspect of the mass to define rectal cancer, as this was a useful reference point for clinicians when they performed a colonoscopy [13, 14]. They classified low rectal cancer as the lowest aspect of the tumor located less than 5 cm from the anal verge. The MERCURY II study and Crane et al. defined low rectal cancer as the distance from the anal verge to the lowest aspect of the mass ≤6 cm [15, 16]. When we used the distance from the anal verge to the lowest aspect of the mass ≤6 cm from previous studies to define low rectal cancer, we found that half of the cases (n=50) were rectal cancer and the other half were anal cancer (n=50). Even when we considered the distance from the anal verge up to 6 cm to the lowest aspect of the mass, we could not differentiate between low rectal and anal cancers with higher
Colorectal cancer affects colon and rectum. Also it occurs in the large intestine. When the cancer is in the last six inches of the rectum, it is known as a rectal cancer. Additionally, colon is in the lower part of the digestive system that processes food and rides the body of waste. Simultaneously, these are referred to as colorectal cancer. Colorectal cancer (CRC) is the most common disease in our society that kills men and women. It is ranked the third most common cause of death among the African American men and women in the United States of America. In addition, colorectal cancer is caused by ulcerative colitis, certain types of diets such as diets that are high in red meat, obesity, smoking, alcohol abuse, and poor exercise. Also, colorectal
Description: I had the chance to work on multiple manuscripts pertaining to colorectal cancer in African Americans and Caucasians. My contribution included compiling the results from each experiment and inputting them into the corresponding manuscript, creation of all necessary tables and figures, as well as proofreading all sections to correct any mistakes.
Globally more than 1 million people get colon cancer every year resulting in about 715,000 deaths as of 2010 up from
The years after the introduction of total mesorectal excision, lead to a major improvement in the survival of rectal cancer. Since its introduction, the five-year survival rates increased from 45%-50% to 75% and the local recurrence rates decreased from 30% to 5%-8%.[1] The technique is based on the principle that dissection in the mesorectal plane, produces an intact fascial-lined specimen, which contains all the blood vessels, lymphatic vessels, and lymph nodes, through which the tumor may disseminate.[2, 3]
Colon cancer is one of the deadliest diseases in the world as most patients don’t have any symptoms in the early stages of the illness.
Colorectal cancer (CRC) is the third most common cancer in the world, with nearly 1.4 million new cases diagnosed in 2012. Almost 55% of the cases occur in more developed regions. About 95% of those diagnosed are adenocarcinomas, malignant tumors that form from glandular structures of the epithelial tissues, and mortality is primarily due to hepatic metastasis. It is predicted that by 2035, there will be 2.4 million cases of colorectal cancer diagnosed annually worldwide. http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/colorectal-cancer-statistics
Colorectal carcinoma (CRC) is one of the lethal malignant diseases and is the third most common cancer and the fourth most common cause of cancer deaths worldwide. It is the third most common cancer in men (10% of all cancers in men worldwide) and second most in women (9.2% of all cancers in women worldwide)(1). It is a slow developing cancer that begins as a tumor or a tissue growth on the inner lining of the large bowel. The most common type of CRC is adenocarcinoma (more than 95%)(2). Even with advancements in the diagnostic technologies the detection is usually late however accurate pre-operative staging has a definite impact in the treatment plan and is important in selecting patients for pre-operative chemotherapy or radiotherapy or both.
In conclusion, cancer fighting nanobots are leading into our future and leading into more new discoveries in the medical field. This new technology will not only help everyone's live but also will help the lives of cancer patients, in medical form. This invention may just be the solution to help save millions of lives in today's
Notwithstanding the immense progression in the cancer chemotherapy field, small-molecule drugs even though they were highly potent, were risky due to their non-specific toxicity due