IMPORTANCE
According to the Centers for Disease Control and Prevention, approximately half of all sexually active individuals will acquire some strain of Human Papillomavirus (HPV) infection in their lifetime [7][8]. Transmission for this virus can be conducted via skin-to-skin contact and does not favor one global location over another [7]. Cervical HPV type infections are the most studied and understood pathology of the viral infection leading to tumorigenesis, but is gaining clinical relevance in oral cancer pathology. To fully understand HPVs pathology, researchers have tried to identify risk factors associated with individuals infected with this virus. Some risk factors associated with HPVs infection include, but are not limited
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The cervix and oral cavity exhibit similar mucosal linings making HPVs cervical infections a model of comparison for HPVs infecting the oropharynx. Approximately 25 percent of all oral cancers are due to a previous HPV infection [4]. Having such a large impact on the development of both cervical and oropharyngeal cancer, developing diagnostic tools are crucial in the overall success of treatment.
The majority of HPV infections go undetected due to an absence of inflammatory response from the host, majority of infections are asymptomatic [2]. Although most of these infections are asymptomatic eliciting no host response, this viral infection has the potential to cause detrimental disease in their host [2]. This type of viral infection was studied in the 1970’s by a scientist who dedicated his studies to understanding herpes simplex virus and its role in cervical cancers ultimately led to the discovery of HPVs [1].
Harald zur Hausen began his studies in medicine, and following his medical internship began studying microbiology [1]. Zur Hausen had a passion for understanding how cancers could result from bacterial infections. He was determined to understand how certain bacteriophages incorporate their DNA into host DNA and how this would alter the overall proliferation of a cell. Zur Hausen focused his research on
Almost all cervical carcinomas are caused by Human papillomavirus (HPV). Cervical cancer can be a life-threating disease. However, over recent years the occurrence of cervical cancer has declined as well as the chance of dying from it. A huge contributing factor to this decline is the importance of a regular pap smear. A pap smear can find cervical pre-cancer before it turns into cancer. Recently, a vaccine for HPV, has been on the market, which provides close to a 100% protection against pre-cancer and general warts. HPV and cervical cancer are two disease that are closely related. However, each disease effects not only similar populations, but also different populations, as well as having its own signs and symptoms, detection procedures,
HPV is the number one sexually transmitted infection (STI) in the United States, and anyone who is sexually active is at risk of contracting the virus. HPV is transmitted through intimate skin-to-skin contact with someone who has the virus, and it is so common that most all sexually active men and women encounter a strain without ever knowing they’re infected (CDC). There are many strains of the HPV virus, some of which don’t cause cervical cancer. To help understand and classify the types of HPV, the terms low-risk and high-risk HPV are used. Some
Cervical cancer is the leading cause of cancerous death, in women, since 1950. Approximately 200,000 cervical cancer patients die each year in developing countries. Strains like HPV 16 and 18 cause about 70% of cervical cancer in women– one of the top causes of death in the world (WebMD, 2010, p.1). In the Unites States, about 10,000 women acquire the disease and 3,700 die annually Human Papilloma Virus (HPV) is directly associated as a cause of cervical cancer. This virus affects the skin and genital area and, in some cases, it can also infect the throat and mouth. Since the HPV is passed from one person to another through skin-to-skin or sexual contact, sexually active people are more prone to this virus. Merck
Human papilloma virus, or HPV, is a sexually transmitted infection, and the more sex partners someone has, the bigger their risk. Now, a study out this week shows there’s a silent epidemic of HPV-related cancers among men. In fact, the study found that men are more likely to be infected with cancer-causing oral HPV strains than women, suggesting there are more throat cancers in men than cervical cancer in women.
Human Papillomavirus(HPV) is the most common sexually transmitted infection in the United States, according to Centers for Disease Control and Prevention(CDC) around 20 million people are infected with HPV and additional 6.2 million people are newly infected every year. According to National Health and Nutrition Examination Survey in 2003-2004 among sexually active women (57% of 14 to 19 years and 97% of 20 to 59 years) HPV was highest prevalent in youngest age group (40% of 14-19 years and 50% of 20-24 years). Infection rates decrease after age of 24 years. There are more than 100 types of HPV viruses out of which 40 cause genital infections. Out of
From 1998 to 2003, the incidence rates for HPV-associated cancers of the tonsils and tongue increased 3.0% per year, while non-HPV cancers of the mouth and throat decreased during this time (Ramqvist and Dalianis, 2010).
Did you know there is more of a link between cervical cancer and HPV than smoking and lung cancer? Cervical cancer is currently the fourth most common cancer in women and the second leading cause of death from cancer in women. Along with those statistics, human papillomavirus is the most common sexually transmitted viral disease amongst men and women worldwide. The prevalence of women having a strain of HPV that ultimately leads to or increases the chance of cervical cancer is highly relatable. What is pathophysiology, signs, symptoms, prevention, and treatments of this ailment? You might ask will be covered in the next few pages of this paper.
Human Papillomavirus (HPV) is a double -stranded deoxyribonucleic acid (DNA) virus that only infects humans with an attraction to both cutaneous and mucosal surfaces such as the cervix, anus, tonsil, and oropharynx (Clark, 2013). HPV is a type of oncogenic virus that goes into the cells and can cause several diseases. Over the years, research has surfaced connecting genital HPV to several types of cancer. There are over a hundred strains of HPV but the most high risk strains, 16 and 18, have been shown to cause vulvar, vaginal, anal, and the most concerning, cervical cancer (Chan, Ng, & Wong, 2012). Genital HPV
Cervical cancer is formed in the tissues of the cervix, an organ that connects the uterus and the vagina. Virtually all cervical cancers are caused by Human papillomavirus (HPV) infections (Schiffman et. al., 2007). HPV is the most common sexually transmitted infection in the United States. According to the CDC, 75% of sexually active people aged 15-49 have the infection at some point in their lives. (CDC). Because HPV infection is usually asymptomatic, infected people do not know exactly when they get the infection. In most cases, the body is able to fight off the virus before any symptom. However, health problems such as genital warts and cancer may
Human Papilloma Virus, known to most people as HPV, is an infectious disease that has become one of top causes of cervical cancer in women. With shocking surge in HPV prevalence, researchers are encouraged to discover more about this virus and how it leads to cervical cancer. Until recently, not many knew what HPV was; there hasn’t been enough research conducted on the virus. In fact, HPV was not significant enough to be taught in the Sexual Education classrooms as an Sexually Transmitted Infection (STI). Years of research yielded information about how one contracts the virus, the symptoms or lack of symptoms, treatment and prevention for HPV.
Human papillomavirus (HPV) is a sexually transmitted disease and is the second most common cause of cancer among women. HPV is group of viruses that causes warts on mucosal surfaces like the cervix, rectum, anus, penis, vulva, and mouth or throat. This condition is associated with ovarian cancer, anal cancer, and oropharyngeal cancer.
Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections in the United States. HPV belong to a family of viruses that cause cell changes in the epithelia resulting in benign skin lesions called warts and verrucae. Type 6 and 11 cause warts and are included under the low risk HPVs,Types 16,18,31,33,45 cause cervical cancer and are included under high risk HPVs(CDC,2014). The virus affects the skin and mucous membrane especially of the reproductive organs. Cervical Cancer and other Ano-genital cancers are seen in women with persistent genital HPV infection. HPV that affects the
In the United States alone, an estimated 34,360 people received a diagnosis of oropharyngeal cancer in 2007; of these, 7,550 (5,180 men and 2,370 women) died. On average, more than 25% of people who develop oropharyngeal cancer will die of the disease, with only 60% surviving for more than 5 years. In fact, oropharyngeal cancer is as common as leukemia and claims more lives than either melanoma or cervical cancer. Since the mid-1970s, oropharyngeal cancer rates have increased approximately 15%, with significant disparities in some population groups. For instance, oropharyngeal cancer prevalence is significantly higher in males than in females. Prevalence is also higher in Hispanic and black males than it is in white males. The risk of oropharyngeal cancer increases with age, and occurrence is highest in persons older than 50 years and peaks between ages 60 and 70 years. However, there has been a startling 5-fold increase in the incidence of oral cancer in patients younger than 40 years, many of whom have no known risk factors. HPV is associated with 15% to 35% of head and neck cancers worldwide. Fifty percent to 90% of OSCCs in the pharynx, tonsil, and tongue are HPV-positive. Chaturvedi and colleagues investigated the impact of HPV on the
According to the National Cancer Institute, there were an estimated 12,360 new cases of cervical cancer and 4020 deaths in 2014. Seventy percent of these cases were caused by the human papillomavirus (HPV). HPV is a virus “spread by skin-to-skin contact” (Alexander, et al. 199). This virus can cause warts on the hands, feet, genital areas, of which 90% are caused from HPV, but in addition to cervical cancer, it may also cause cancer in many other parts of the body including head, neck, anal, and penial (Krishnan 2). All of this sounds pretty scary, however, much of it could be avoided with a simple series of HPV vaccinations. All of
The International Agency for Research on Cancer (IARC), recognized that HPV types 16 and 18 are carcinogenic in humans, in addition, HPV is strongly associated with the development of OPSCC. HPV-16, is believed to be the risk factors for a subset of HNSCC and the most strongly associated with oropharyngeal squamous cell carcinomas (OPSCC). HPVs are divided into cutaneous and mucosal types, based on their tissue tropism, in addition they are divided into low- risk and higher-risk types of HPV, HPV types 6 and 11 are benign and mostly found in oral squamous papillomas and common warts, meanwhile, HPV types 16 & 18 are high-risk and integrated into the host cell of the DNA in malignant lesions. Furthermore, More than 50% of the cancers are found to harbour HPV 16 DNA, and it is considered as a hallmark of malignant transformation. (Krueger H 2010).