Bioinformatic Analysis of Functional Proteins involved in obesity associated with diabetes
Sometimes the body cannot produce enough of insulin (a hormone produced by the pancreas) to facilitate glucose found in blood into surrounding cells; this can sometimes lead to hyperinsulinemia (high blood glucose concentration). People who have this condition are usually diagnosed with Diabetes mellitus, and according to the National Diabetes Statistics report, if hyperinsulinemia is not checked over time it can lead to a variety of diseases which include: stroke, renal failure, heart disease, foot and eye problems, dental problems, and even nerve damage. There are different classifications of diabetes mellitus such as type-2 diabetes mellitus
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They identify the more common gene-encoding proteins that link obesity and diabetes.
The study design is broken down into two phases; phase one is to identify and extract literature that focuses on gene-encoding proteins involved in the link between obesity and diabetes. Once these gene-encoding proteins are identified, the sequences, in FASTA format, are extracted from the National Center for Biotechnology Information (NCBI). Phase 2 then analyzes those genes by utilizing the Multiple Sequence Alignment provided by the ClustalW tool found online. With the sequence aligned phylogenetic tress and alignment scores can be visualized for better analysis of potential homologies. Results identify seventeen proteins one of them being resistin; resistin has a number factors that contribute to obesity including the increase in fatty acid and adipocytokine levels. This is important because adipocytokines have been linked to the development of insulin resistance. Resistin has been thoroughly studied in regards to the link it plays in obesity and diabetes. One study that this article highlights is that insulin, FFAs, and TNF-a (known resistin inhibitors) are increased in obesity, however, this statement contradicts other studies performed in human and rodent students making resistin a controversial protein linking obesity and diabetes. Other gene-encoding proteins that have been linked to obesity and diabetes are ADIPOQ, MAPK8, and ICAM1.
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Diabetes is a common disease, which can be a serious life-long illness caused by high level of glucose in the blood. This condition is when the body cannot produce insulin or lack of insulin production from the beta cells
Diabetes, Diabetes Mellitus, is a chronic illness this means that it has no cure and the symptoms persist over a long period of time. This illness is a result of an imbalance of hormones, insulin, produced in the pancreas. Insulin plays an important role in how the body uses food. Insulin enables the cells in the bloodstream to absorb and use glucose for fuel. If the pancreas produces too little or no insulin or if the insulin doesn’t work properly the person may become diabetic. Therefore, diabetics are not able to properly convert food into fuels needed by the body to function, which can seriously lead to physical consequences.
Diabetes is a metabolic disease in which the body’s inability to produce any or enough insulin. This causes elevated levels of glucose in the blood. This can be a very life threatening disease if left un treated. One of the symptoms are hunger and fatigue. If your body can’t get enough insulin the glucose
Diabetes mellitus is a condition where the hormone insulin is not being naturally made by the pancreas, is being made in small amounts or is not being used properly by the body. If left untreated, the most sever type of diabetes would lead to certain death because of the lack of glucose in the cells and vital organs.
Diabetics have an insulin problem Diabetes is a result of insulin not performing its job correctly. Since insulin does more than remove glucose from the bloodstream, including producing proteins, storing fats, and other metabolic processes, diabetes can have severe consequences. If it is not treated properly diabetes can lead to heart disease, stroke, eye problems (including blindness), kidney failure, problems with teeth and gums, male sexual problems, nerve problems, and circulation problems. The circulation problems could result in foot or leg amputation (Reddy 2).
Diabetes is a disease in which the body does not produce enough insulin, a hormone needed to convert the sugars and starches that we eat into energy needed for daily life. The cause of the disease is a mystery, but genetics and environment seem to play major roles. There are two kinds of Diabetes, Diabetes Insipidus and the more common Diabetes Mellitus. Diabetes Insipidus is a rare disease caused by a deficiency of vasopressin, a hormone of the posterior pituitary gland that
Diabetes is one of the most prevalent diseases to this day. With over 171 million cases of diabetes all over the world, this disease is spreading exponentially fast. Lesser known as Diabetes Mellitus, this disease is all about the amounts of sugar in one's body. Glucose, in particular. Glucose is the powerhouse of the body. It helps run your body by transforming into the energy that we use to function on a daily basis. Whether or not one's diabetes is minor or even off the charts it can lead to terrible outcomes. These include stroke, blindness, vascular disease and heart disease. As mentioned before, the major symptom of diabetes is that too much sugar is in one's body. This is similar to a disease previously mentioned, hemochromatosis. However,
Diabetes mellitus Type 2 also known as adult onset diabetes is the most common form of diabetes today. Type 2 Diabetes can be caused by a lack of insulin created or the cells in the body being insulin resistant. Insulin is needed for the body to be able to use glucose (sugar) as energy for the cells. Insulin resistance causes your body to create more insulin than you need in your body to compensate for the insulin your cells are not able to use. Over time the pancreas fails to make extra insulin. This is why Type 2 Diabetes is seen more in people over 65, according to the American Diabetes Association. Without a healthy body, the pancreas will be unable to produce extra insulin to account for the transferring of an adequate amount of blood glucose to the cells. With a low glucose level in the cells, the cells fail to fuel the body which can lead to cells being energy starved. A high glucose level in the blood can lead to damages to the heart, eyes, kidneys and nerves over time. Even though Type 2
Diabetes is a lifelong disorder in which the body does not produce or properly use insulin, a hormone that regulates blood sugar by converting sugar, starches, and other foods into engery necessary for daily life. The problem may be caused by too little insulin or the body 's resisitance to using the insulin that is secreted by the pancreas, a small organ that lies behind the lower part of the stomach (Laberge, 2011). As a result, glucose in the blood cannot be absorbed or used by the cells of the body. There are two major types of diabetes mellitus, type 1 and type 2.
Diabetes mellitus is a metabolic disease that is characterised by hyperglycaemia. This is a result from a deficiency in insulin action and secretion. Symptoms of hyperglycaemia include polyuria, polydipsia, weight loss, blurred vision and on some occasions, polyphagia. If the disease becomes chronic is patients, it can lead to dysfunction, long-term damage and failure of organs http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613584/?report=classic.
Diabetes is a chronic condition that results in high sugar levels in the body; it occurs when the body can’t produce insulin or utilize it as it’s required. Insulin is a hormone that enables the body to use the glucose or sugars from the food consumed. A lot of people have glucose levels above the usual range, although not high enough to be termed as diabetes, this is known as pre-diabetes and the risk of developing full-blown diabetes is high. It’s vital for the condition to be diagnosed early enough because it worsens when medical intervention isn’t sought. There are two types of diabetes namely:
Diabetes is a disease in which insulin, a hormone that aids glucose from food to enter body cells and provides cells with energy, is not produced properly. In most cases, the pancreas does not produce insulin, but in other cases the body cannot use the insulin the pancreas produces. Although diabetes can only be diagnosed with a blood test, there are several symptoms that may indicate that an individual has the disease. These include frequent urination, excessive thirst, unexplained weight loss, and sudden changes in vision. In addition, tingling in hands and feet, frequent fatigue, sores that are slow to heal, and more infections than usual are symptoms of diabetes.
Did you know there are approximately 1,100 genetic diseases in this Earth? Diabetes is one of them. Diabetes is a disease in which the body’s ability to produce or respond to the hormone insulin is impaired, resulting in abnormal metabolism of carbohydrates and elevated levels of glucose in the blood and urine. Diabetes is a number of diseases that involve problems with the hormone insulin. Normally, the pancreas releases insulin to help your body store and use the sugar and fat from the food you eat. Diabetes can occur when the pancreas produces very little or no insulin, or when the body does not respond to insulin.
Diabetes is a disease that affects the use of insulin in the body. According to the Merriam Webster Online Dictionary diabetes mellitus is a ” disorder of carbohydrate metabolism caused by a combination of hereditary and environmental factors and usually characterized by inadequate secretion or utilization of insulin, by excessive urine production, by excessive amounts of sugar in the blood and urine, and by thirst, hunger, and loss of weight” (“Diabetes Mellitus”). This disease not only impacts the amounts of sugar in the blood, it also has lasting effects on the rest of the body. Diabetes impacts the body and its systems negatively if the body’s blood sugar levels are not treated or maintained properly.
Diabetes Mellitus is a metabolic disorder characterized by hyperglycemia resulting from a lack of insulin, a lack of Insulin effect, or sometimes both. Diabetes can lead to serious complications if not maintained properly. Long term consequences of poorly controlled diabetes mellitus include blindness, kidney failure, heart failure, stroke, and foot or leg amputations. There are three classifications of Diabetes these include type 1, type 2, and gestational diabetes. .