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Chlororphyrin And Therapeutic Analysis

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Complexation of porphyrin with the metal will cause the shifts of Q bands in the UV-Vis spectra in the range of 500-700 nm as shown in Figure 2.7. This can be observed by the disappearance of two Q bands out of four as the porphyrin undergoes the change from D4h symmetry to D2h symmetry (Rita Giovannetti, 2012). The Q-bands were denoted as α and β. The coordination of porphyrin to Ni(II), Sn(IV) or Pd(II) which can form stable square planar complexes generally consists of a higher α peak (Figure 2.7 (A)), while the coordination of porphyrin to Cd(II) which forms a complex that can easily be displaced by protons will show a higher β peak (Figure 2.7(B)).

The common solvents and counter-ions employed in the synthesis metalloporphyrin are chloroform, methanol, dimethylforamide, acetate buffer, pyridine, metal carbonyl and acetylacetone. In general, the selection of solvent depends on the solubility of porphyrin. For example, the chloroform was selected for metallation of meso-tetraphenylporphyrin (TPP) due to the solubility of TPP in chloroform. Besides, the metal counter-ion as “carrier” of metal should be considered as well, as the solubility of metal salt also affect the metallation of porphyrin. …show more content…

In nature, porphyrins such as hermatoporphyrin IX, coproporphyrin and uroporphyrins are water soluble. Since the isolation of these porphyrins, the chemistry water-soluble porphyrins were intensively studied to develop biological useful device. The notion “water-soluble porphyrin” suggests at least water soluble in pH 1-14 only consider as water-soluble porphyrin. General, water-soluble porphyrin can be divided into three classes: positively charged porphyrin, negatively charged porphyrin and neutral porphyrin (Simonnaeux et al., 2011) as shown in Table

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