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Chronic Kidney Disease Analysis

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Chronic kidney disease (CKD) is a leading cause of the critical mortality and morbidity, the Global Burden of Diseases 2010 study reported that CKD contributes to approximately 740,000 deaths annually, making it the 18th leading cause of death (Benigni et al. 2010, Lozano et al. 2012). CKD is a progressive condition as either kidney damage or decreased kidney function over time (Figliuzzi et al. 2014). The main causes of CKD include glomerulonephritis, diabetic kidney disease, hypertensive nephropathy, polycystic kidney disease and other factors, which gradually decrease the glomerular filtration rate (Karczewski and Malkiewicz. 2015). The major outcomes of CKD include progression to kidney failure, complication of decreased kidney function, and cardiovascular disease. Moreover, patients with CKD are at high risk for progression to the end stage renal disease (ESRD) (Levey et al. 2003). The increasing number of patients with CKD, medicare spending on these patients exceeds $29 billion annually and expecting an expense of almost 3~5% of annual healthcare budgets in Unite state (Collins et al. 2012, Burgkart et al. 2014). …show more content…

2014). Dialysis treatments partially replaces the filtration properties of the kidney, offer temporary solutions for patients, however, does not address the loss of the hemostatic and endocrine function of the kidney (Sullivan et al. 2012). Furthermore, the outcomes of the patient in dialysis are still disappointing, associated complications which accelerated cardiac disease and infection contribute to an annual mortality rate exceeding 25% (Figliuzzi et al. 2014). Medical therapies has increased survivorship of those with CKD, transplantation remains the only available curative treatment (Song et al.

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