Essay On Bacteriophages

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Multidrug resistant bacteria are quickly becoming an issue around the globe, and a specific strain, Escherichia coli sequence type (ST) 131 has shown a propensity to use the intestinal tract of humans and household pets as a reservoir, all while exhibiting a high risk of infection to individuals with immune-compromised systems (Green et al. 2017). One method of countering the antibiotic resistant characteristics of this strain is to combat via the use of bacteriophages, organisms which can infect and devour the bacteria without harming the patient. This paper will briefly discuss bacteriophages, their benefit over antibiotic treatments, and the method in which bacteriophages are being experimented with to treat extra-intestinal …show more content…

1997). This specificity characteristic, combined with the sheer number of different bacteriophage species, opened up a new and potentially exciting medical use, and the issue of resistance in ExPEC ST131 and other bacteria led to some of the first phase I clinical trials of bacteriophage therapies to be approved by the FDA in 2009, which were then carried out on treatment of venous leg ulcers on human patients (Rhoads et al. 2009).
Numerous Escherichia coli strains are identified as having interaction with humans, with both necessary and also harmful purposes. ExPEC in particular however, are a broad E. coli pathotype that are capable of asymptomatically colonizing both human and canine gastrointestinal tracts, as well as sites situated away from the intestines (Green et al. 2017). ExPEC ST131 clonal group has emerged from this species to be not only multidrug resistant but able to accommodate deadly virulence factors. Among the 750,000 cases of sepsis in the US annually (Wang et al. 2010), ST131 is now the number one most frequently found antibiotic resistant strain in the blood of US adults (Ani et al. 2015). To isolate bacteriophages to treat this strain, researchers sought phages with lytic activity against avian pathogenic E. coli, because of known

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