A Review of " Intrinsic Hippocampal Activity as a Biomarker for Cognition and Symptoms in Schizophrenia"
By: RJ Parrish
Abnormal Psychology: 10:00 Class
March 6th 2016
According to the National Institute of Mental Health (NIMH) schizophrenia is a "chronic and severe mental disorder that affects how a person thinks, feels, and behaves. Although schizophrenia is not as common as other mental disorders, the symptoms can be very disabling."(NIMH,2016). Those with this diagnosis can lead very difficult lives, depending on the severity of their symptoms. For example, some people "may seem like they have lost touch with reality," (NIMH, 2016) seeing a world many of us cannot imagine. Finding an early biomarker in any
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554) The research done may have only been a small study of 56 individuals, but I believe is a good start for a better understanding of schizophrenia in the brain. These findings tell us that the hippocampus might play an important role in the future diagnoses of schizophrenia. Discovering such a significant biomarker could completely change the way we find and treat patients in the future.
References:
1) National Institute of Mental Health (2013). Schizophrenia. Retrieved March 10, 2016, from http://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml
2) Jason R. Tregellas, Ph.D. Jason Smucny, M.S. Josette G. Harris, Ph.D. Ann Olincy, M.D. Keeran Maharajh,Ph.D. Eugene Kronberg, Ph.D. Lindsay C. Eichman, B.S. Emma Lyons, B.S. Robert Freedman, M.D, (Published: Nov 12th , 2013). Intrinsic Hippocampal Activity as a Biomarker for Cognition and Symptoms in Schizophrenia. The American Journal of Psychiatry, 549-554.
2) Joan Arehart-Treichel (Published: June 16th, 2014). Same Brain Circuits Linked With Psychosis in Two Disorders. Psychiatric
Using anatomical likelihood estimation (ALE), a meta-analyses of forty- two studies demonstrated extensive gray matter deficits in frontal, temporal, cingulate and insular cortex and thalamus in schizophrenia (SZ) when compared to healthy controls. Similarly the same meta-analyses of fourteen studies showed gray matter reductions in anterior cingulate and bilateral insula in bipolar disorder (BD) when compared to healthy controls (Ellison-Wright I and Bullmore E, 2010). However the regions of grey matter reduction were less extensive in bipolar than schizophrenia. Another recent meta-analyses conducted using revised ALE showed consistent gray matter decreases in patients (SZ, BD) in bilateral anterior insula, dorsal anterior cingulate (dACC), dorso/ventro medial prefrontal cortex, thalamus, amygdala, hippocampus, superior temporal gyrus along with gray matter increases in
Expert’s reason that unevenness in the complicated interconnected chemical responses of the brain connecting the neurotransmitters dopamine and glutamate, and maybe others, performs a part in schizophrenia. Neurotransmitters are elements that permit brain cells to interconnect with each other. Experts are acquiring more about brain chemistry and its connection to schizophrenia. Similarly, in small methods the brains of people with schizophrenia appear diverse than those of healthful people. For instance, fluid-filled holes at the middle of the brain, called ventricles, are greater in certain people with schizophrenia. The brains of people with the disorder similarly manage to have less grey matter, and certain
Schizophrenia is a brain disease. Many studies have been conducted regarding the brain localization of schizophrenia. One study established that schizophrenia is characterized by significant loss in the grey matter of the brain. The loss was detected to be up to 25% in some areas and the damage was seen to begin at the parietal (outer) regions of the brain then spreading to the rest of the regions of the brain over a period of about five years ADDIN EN.CITE Rajagopalan1998923(Rajagopalan, MacBeth, & Varma, 1998)92392317Rajagopalan, MMacBeth, RVarma, SLXXY chromosome anomaly and schizophreniaAmerican Journal Medical GeneticsAmerican Journal Medical Genetics64-65811998( HYPERLINK l "_ENREF_9" o "Rajagopalan, 1998 #923" Rajagopalan, MacBeth, & Varma, 1998). Another study showed that patients who had the worst loss of brain tissue also exhibited the worst symptoms of schizophrenia such as hallucinations, psychotic and bizarre thoughts, hearing voices, depression and delusion ADDIN EN.CITE Conklin2002797(Conklin & Iacono, 2002)79779717Conklin, Heather M.Iacono, William G.Schizophrenia: A Neurodevelopmental PerspectiveCurrent Directions in Psychological ScienceCurrent Directions in Psychological Science33-371112002Sage Publications, Inc. on behalf of Association for Psychological Science09637214http://www.jstor.org/stable/20182759( HYPERLINK l "_ENREF_2" o "Conklin, 2002 #797" Conklin & Iacono, 2002).
Schizophrenia is a psychotic disorder characterized by distorted thinking, impaired emotional responses, poor interpersonal skills and a distortion of reality. It is the most common of psychotic disorders that, in most countries around the world, affects around 1 per cent of the population. In terms of explanations for the disorder, two central types of explanations arise – psychological explanations and biological explanations. Whereas psychological explanations tend to focus on cognitive, emotional and environmental factors that may cause the disorder, biological explanations tend to focus on genetic, biochemical and neuro-anatomical factors as the cause of the
Schizophrenia is a psychological disease with an unknown treatment. Its onset starts in early adult hood on average. There are many studies showing links to genetics and environmental causes. In this paper I will discuss many of the signs and symptoms of schizophrenia along with how it is diagnosed, imaged with MRI, and the difficulty in treating this disease. More treatments for schizophrenia may be revealed with the further advancement of imaging technology. Schizophrenia is a disease that affects the most complex structure in the human body, the human brain. The more research that is continued on the smaller segments of the different areas of the brain with imaging modalities the closer we get to
Russo SJ, Nestler EJ. The brain reward circuitry in mood disorders. Nat Rev Neurosci. 2013;14(9):609-625.
While there is no cure for schizophrenia, research is leading to new, safer treatments. Experts also are unraveling the causes of the disease by studying genetics, conducting behavioral research, and by using advanced imaging to look at the brain’s structure and function. These novel approaches hold the promise of new, more effective therapies.
The original studies performed in order to comprehend the pathology of the brain in psychosis
Worldwide about 1 percent of the population is diagnosed with schizophrenia, and approximately 1.2% of Americans (3.2 million) have the disorder. About 1.5 million people will be diagnosed with schizophrenia this year around the world. In the United States, this means about 100,000 people will be diagnosed, which translates to 7.2 people per 1,000 or about 21,000 people within a city of 3 million who are likely to be suffering from schizophrenia (Rashmi Nemade , Ph.D. & Mark Dombeck, Ph.D. Schizophrenia symptoms, patterns and statistics). Schizophrenia is a severe mental illness that affects the way a person thinks, acts and expresses emotions. People
Mental health has been studied for centuries now. There have been fast differences major evolutional discoveries and changes since mental health has been researched and studied. Many theorists have been pioneers in their respective studies and laid the blueprint for what it is today. One of the interesting diagnosis’s during the early development is how Schizophrenia is a diagnosis that has been misunderstood over the centuries. The criteria that would determine one such a label, has shifted drastically. Although it has shifted and the information we have today is much more polished due to the amount of research and studies that have taken place, it’s important to learn and know the history behind how schizophrenia came to be and how it was coined to become such a noticeable and intricate part of diagnosis’s in psychology. Leading the way in the foundation and discovery of
Schizophrenia is a serious mental disorder that affects millions of people and it should not be underestimated or ignored.
Schizophrenia has been defined as a mental disorder characterized by a breakdown in mental thinking and a poor emotional response. This disorganization hasn’t till now acquired a clear understanding of the mechanisms that lie behind (Harrison 1999) but researchers suggest an increase in the dopaminergic transmission in the prefrontal cortex coupled to an inhibition of the glutamatergic pathways, majorly at the level of NMDA receptors (Wen-Jun Gao). For more than 50 years, the dopamine hypothesis had been considered the mother of the theories of schizophrenia. Van Rossum first proposed it in 1966 suggesting that a hyperactivity occurring at the level of the mesolimbic dopamine pathway is the mediator of positive symptoms of schizophrenia
Academic consensus regarding the etiology of most mental disorders is often tough to achieve due to a myriad of polygenic effects and complex gene-environment interactions; however, certain disorders such as Schizophrenia pose even more difficulty. Schizophrenia is a psychiatric condition that is marked by various positive and negative symptoms that cause fluctuations in cognitive ability and impose distorted experiences onto the patient (Pinel, 2011). Positive symptoms are defined as extreme and maladaptive variations on normal functioning, which include symptoms such as delusions and hallucinations (Xavier & Vorderstrasse, 2017); conversely, negative symptoms
Along with the contributions of Kraeplin and Bleuler, other important studies on neurocognition of schizophrenia emerged from two different branches of psychology which are clinical neuropsychology and experimental
Magnetoencephalography is utilized to recognize examples of neural action in individuals with schizophrenia contrasted with those who do not have,