Layer-by-Layer Approach for Making Microcapsules
Muhammad Faiz Omar (201308264)
4th December 2014
Abstract
The fabrication of hollow multilayer microcapsules in the beginning is initiated by layer-by-layer (LbL) self-assembly technique of oppositely charged polyelectrolyte on colloidal template followed by core decomposition. The main concept of microencapsulation is to protect the contents of fabricated microcapsules from the harmful environment in which it is surrounded. In this literature review, I shall outline the technique of microcapsules encapsulation employing LbL approach, lists of polyelectrolytes and templates and application of microcapsules.
Introduction
Over the past decades, nanometre-sized or known as microcapsules have been benefited the approach of Layer-by-Layer(LbL) technique due to the ability of tailoring their properties(e.g., size , shape, colloidal stability, surface-functionality, composition) that are biocompatible and biodegradable.1-3,10They are broadly used in many applications including food technologies, cosmetics, textiles industry and pharmaceuticals. The LBL assembly of multilayers are fundamentally built up by the alternating deposition of oppositely charged polyelectrolytes onto a sacrificial template such that the charge oscillates between positive and negative with each layer.1,4 The establishment of nanocoatings using LbL assembly method distinguishes itself in its intelligibility compared to the more conventional method. The
Whenever a monolayer is attached to a metal surface, the wetting properties and behavior can be significantly affected (Yuan & Lee, 15). In practice, densely-packed self-assembled monolayers (SAMs) can be used to modify the macroscopic properties of a solid surface (Dilimon et al. 202). Changes in wetting properties occur due to changes in the angle made by a liquid droplet whenever it is in contact with the surface. This phenomenon is significant in several contexts for example, in industrial contexts: this property is used to evaluate the cleanliness of semiconductor wafers. In such contexts, contact angles measurements are widely used. Control of this property is also useful during penetration of insecticides or pesticides into plants, and waterproofing of materials (Yuan & Lee, 25). While the former focuses on maximization of wetting, the latter case seeks to minimize liquid-induced wetting (Yuan & Lee, 28).
ABSTRACT: Copolymers of aniline and o-phenylenediamine / kaolinite composites were synthesized by 5:1 molar ratios of the respective monomers with different percentages of nanoclay via modified in situ chemical co-polymerization. The results were verified by measuring the FT-IR and UV-vis absorption spectra for PANI-o-PDA / kaolinite composites. The thermal behaviour of the copolymer and composites was studied. PANI-o-PDA / kaolinite composites were thermally more stable than pure copolymer. Surface morphology of copolymer composites was recorded at different magnification power by SEM which revealed whitish micrometric beads distributed all over the field with particle size in the range of 0.122 μm to 0.233 μm. This work demonstrates that
There has recently been a lot of interest in PDMS based microfluidic systems due the numerous advantages it offers compared to glass and silicon [Kong J et al, 2009; Tanyu Wang et al, 2013 and Alphonsus et al, 2010]. PDMS is easy to fabricate, flexible, optically transparent and can irreversibly bind to itself through the application of oxygen plasma. Another major advantage is that PDMS based devices can be fabricated in normal laboratory conditions as opposed to clean room conditions that are expensive to maintain and access. PDMS is also hydrophobic that is desirable for
Nano-composite plastics and carbon nanotubes have been utilized for industrial and consumer packaging, the later offering an improved packaging solution for electronics components by making the materials used lighter and stronger. Nano-porous silica is a high porous, low-density solid material that supports various temperatures making it a great insulation product that can be applied in a wide range of fields from pipe insulation to refrigerators and even microelectronics. Nanoparticle based colloids are employed in the manufacturing of sunscreens, paints, and printer inks and nano-coatings can be applied in order to obtain scratch resistant surfaces. Composite nano-materials can be considered the basis for all the other current and future commercial applications of nanotechnology.
using Aleve Liquid-gels because the naproxen sodium inside the liquid-gels may cause problems in unborn child and/or during birth. Aleve Liquid-gels should be kept out of the reach of children and should be taken with a full glass of water. Adult consumers and children over 12 can take one capsule every eight to twelve hours. Two capsules can be taken within the first hour but three capsules should not be taken within a 24 hour period. Inactive ingredients in Aleve Liquid-gels consist of FD&C blue #1, gelatin, glycerin, lactic acid, mannitol, pharmaceutical ink, polyethylene glycol, purified water, sorbitan, and sorbitol.
Fabrication of nanomaterials with strict control over size, shape, and crystalline structure has become very important for the applications of nanotechnology in numerous fields including catalysis, medicine, and electronics. Synthesis methods for nanoparticles are typically grouped into two categories: “top-down” and “bottom-up” approach. The first involves the division of a massive solid into smaller and smaller portions, successively reaching to nanometer size. This approach may involve milling or
into p-nitrophenylate, a yellow colored compound. The quantity of p-nitrophenylate was evaluated by measuring the absorbance at 405 nm. As a result, the percentage of cell attached on the LBL film can be further assayed. The viability of human fibroblast cells seeded on COL/TA, COL/PSS and COL/HEP film after 22 h is shown in Figure 4. Tissue culture polystyrene plate (TCPS) was used as control. Phosphatase activity on COL/TA films is pretty similar than on TCPS. We can assume that the number of cells is therefore similar, showing no obvious cytotoxicity of this surface. It is shown that the COL/TA film has the highest activity of phosphatases (0.380 ± 0.016) compared with COL/PSS and COL/HEP films. Also, it can be found that COL/HEP film (0.235 ± 0.011) has higher phosphatases activity than COL/PSS film (0.140 ± 0.012). Related to these observations, we can assume that COL/PSS and COL/HEP show, to some extent, cytotoxicity. Note, the different polyelectrolyte used for the outer layer may influence the cell viability.
Throughout the process of one’s essay it will be conveyed that, microbeads which are found in cosmetic products are an unsustainable form of exfoliant which is polluting marine environments and consequently, generating questions regarding the legality of the substance all together. This will be portrayed by a collection of evidence outlining the detrimental effects on marine ecosystems, the potential illegality of the product which is present in the Canadian Environmental Protection Act, 1999 and also, the various initiatives and campaigns around the world that are seeking to ban microbeads. One will now outline the major paper sections, and the evidence that will be used to convey one’s thesis within the sections.
The PCL/Poly membrane by electrospinning the model proposed may not have demonstrated effective performance for therapy guided bone regeneration when used alone. However, improvements as standardization in its production or as their physical structure, could take it to be studied as a biomimetic scaffold or as a carrier of other substances that promote guided bone
The selection of the benzidine and o-phenylenediamine monomers for polymerization, is to form the corresponding potential poly(benzidine-co-o-phenylenediamine) emeraldine base which obviously, comprise of a particular quantity of the surface amino groups, supporting the binding of organic units that have acidic features with the composite surface [2-3]. For example, thyrosine, tryptophan, phenylalanine, and doxorubicin have been revealed that the nanoparticles are promising as drug carriers [2-3] or antibacterial reagents [ ].
Silver nitrate AgNO3 (≥99.0%) and PVP (Average molecular weight ~55,000) were purchased from Sigma-Aldrich. Ethylene glycol (EG) and Hydrochloric acid (HCl) were purchased from Merck specialities Pvt Ltd. All the chemicals were used as received without any purification. We synthesized silver nanocubes (Ag NCs) by a typical polyol method. In a typical synthesis, 12.5 mL of ethylene glycol was poured in 50 mL of round bottom flask and heated at 140°C for 1 h under stirring. An amount of 2.5 mL of HCl solution (3.3mM in EG) was quickly injected into the reaction mixture. After 10 min, 7.5 mL of AgNO3 solution (94mM in EG) and 7.5 mL of PVP (147mM in EG) solutions were simultaneously injected into the stirring solution. The reaction mixture was
Materials Used. For silver nanoparticle synthesis, silver acetate (AgAc-166.91g/mol) was procured from Sigma Aldrich and oleylamine from. Thiol terminated polystyrene (PS-SH) Mn-1100, Mw-1230, PDI-1.12 was procured from Polymer Source Inc. Canada. The polymer for micelles Polystyrene-b-4vinylpyridine (PS-b-4VP) Mn(PS)=18,500; Mn(P4VP)=40,500; PDI-1.10 was procured from Polymer Source Inc. Canada.
Breast implant with nano ‘bed of- nails deter cancer cells. This technology is an implant that appears to deter breast cancer cells growth. It is made from a common polymer that is the first to modified at the nanoscale. It has nanoscale surface that impedes cancerous cells from gathering the nutrients they need to thrive because of the lack of blood-vessel. The implant attracts healthy breast cells formation instead. Thomas Webster, associate professor, created a breast implant with bed of- nails surface at the nanoscale that deters cancer cells from dwelling and thriving. It’s a surface that’s hospitable to healthy breast cells and less so for cancerous breast cells. The bed of- nails inside the surface of the implant prevents cancerous cells
Xianglong et al. found similar results (2) in their paper. The cell number on the Nanotube with 30 nm diameter was significantly higher than the one without the nanotubes. For each incubation time, the surface with the absence of nanotubes had the least cell adhesion. Even with respect to the filopodia the nanotubes showed similar behavior. On the surface withy nanotubes of 30 nm diameter, the actin of the cells was organized along the spreading direction and had formed many filopodia. Interestingly, most of the cells on the surface of 80 nm diameter group maintained a round or oval shape, but the cells also stretched out many filopodia. Cells on the three nanotextured surface had stretched out many filopodia and some lamellipodia. In particular, the cellular cytoskeleton of cells on the 80 nm surface achieved a more homogeneous and extensive arrangement compared with those of the other three groups. The shapes of cells grown on the SLA + 30 nm and SLA + 80 nm surfaces were clearly different. It was observed that those grown on the SLA + 80 nm surface were the most irregularly shaped, while those grown on the SLA + 30 nm surfaces had relatively regular shapes.
Polylactic acid polymers (PLA) appear to be a very promising material for use as a