Maintaining A Constant And Balanced Internal Environment

Progression of osteoarthritis involves of three stages. Stage 1 start from cartilage matrix breakdown follow by cartilage fibrillation and erosion. Disease continues to progress to stage three where synovial inflammation started. With inflamed synovial, synovial membrane produced cytokines, particularly inflammatory cytokines and growth factors which both able to diffuse through synovial fluid and enter the cartilage. This will activates pro-inflammatory cytokines (Pelletier et al, 1999).In short, cartilage breakdown or degrade will lead erosion and release pro-inflammatory cytokine which in turn contribute to joint destruction. In an osteoarthritis knee, Examples of pro-inflammatory cytokines are interleukin-1, IL-1 and tumour necrosis factor alpha, TNF-α.

Homeostasis is an organisms way of stabilizing and keeping a consistent internal environment within the body while our external environment is always changing. The endocrine system plays a big role in this as hormones help regulate the cells. The stimulus controls the release of hormones into the blood, it either increases or decreases the amount released. The receptor then detects the change, and sends the information to the control center. The control center then analyzes the information and decides the appropriate response. The effector then receives the information sent by the control center, the effector either puts out negative feedback or positive feedback. Negative feedback will shut off the stimulus, and positive feedback will fasten

Glucosamine stimulates production of glycosaminoglycans and proteoglycans, the two essential building blocks of cartilage. Advocates of the treatment say that artificially synthesized glucosamine supplements can jumpstart glucosamine production within joints. Choindroitin is made of many of the same molecules as glucosamine, and essentially serves the same purpose. The long-lasting pain relief and functional improvements that are reported by users of the supplement come as a result of anti-inflammatory agents, an increase in cartilage building activities, and a reduction in the enzymatic destruction of cartilage. Along with a termination in the progression of joint damage, reversal of damage is also highly likely. The rapid pain relief upon initiation of a glucosamine

Osteoarthritis, the most common type of arthritis, is most prevalent in older patients. Osteoarthritis is a degenerative bone disease due to the gradual loss of cartilage. A primary type of osteoarthritis is hip arthritis where it is caused by joint injury, increasing age, and being overweight (“Hip Osteoarthritis,” n.d.). However, osteoarthritis can also be caused by immature joints, inherited defects in cartilage, and extra stress on a patient’s joints (Hip Osteoarthritis,” n.d.). As a result, hip arthritis becomes a huge detriment in patient’s social, emotional, physical lifestyles. In order to treat hip arthritis, doctors choose from a variety of non-drug treatments, medications, and surgeries. Uniquely, I was inspired to research about the treatments of hip arthritis because my very own brother was pronounced with hip arthritis a few years back. Therefore, his determination to battle this disease encouraged me to investigate about the treatment of hip arthritis.

There are three types of muscle tissue: skeletal, cardiac and smooth muscle. Skeletal muscle is attached to bones and helps with movement. Cardiac muscle is found the heart helping the heart to contract and pump blood through an organism. Smooth muscle lines the walls of organs in the digestive and urogenital tracts.

Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage on the ends of your bones wears down over time. Most people don't know they have it because the aches, tenderness, stiffness dont feel like arthritis until x-rays prove it. Just like regular arthritis, it affects the skeletal system. This is because it causes the bones to wear and then become stiff.Primary osteoarthritis, osteoarthritis not resulting from injury or disease, is mostly a result of natural aging of the joint. With aging, the water content of the cartilage increases, and the protein makeup of cartilage degenerates. Eventually, cartilage begins to degenerate by flaking or forming tiny crevasses.Secondary

The symptoms of osteoarthritis are usually very slow to manifest worsen over time. Symptoms include joint pain, tenderness in joints, joint stiffness, loss of flexibility, a grating sound in the joints and hard lumps around the joints. Though the symptoms can be present in any joint, it’s usually more evident in the affected person’s joints in their knees, hands, hips and spinal column. People at risk are again older people especially women, obese people, those who have had joint injuries, people employed in manual labor jobs, and certain diseases such as diabetes, gout and rheumatoid arthritis where the side effect is osteoporosis. As in osteoporosis, there is no cure for osteoarthritis and the symptoms just keep worsening in patients, but it can be prevented and / or the slow the progression of the disease by staying active and by staying in good physical shape, maintaining body weight. This also help them improve pain and joint

The gradual wear and tear that is put on the joints of our human body causes cartilage to begin to gradually

Osteoarthritis is a degenerative joint disease that stems from the breakdown of cartilage of the bones as a result of traumatic injuries, joint overuse, obesity, or genetic and metabolic diseases. Osteoarthritis mainly affects older woman in the knees, hips, hands and spine. Sufferers experience inflammation, swelling, and pain in affected joints, eventually causing joint stiffness and limitation of movement, misalignment, and knoblike bone growths in the hands (Stark). While there is no known cure for OA, there are many treatment options to help preserve physical function

Osteoarthritis is a degenerative joint disease characterized by a fragmentation and erosion of the articular cartilage, which becomes soft, frayed and thinned with alteration of the subchondral bone. It also characterized by the hypertrophy of the bone, changes accompanied by pain and stiffness which finally leads to loss of

When the point of two or more bones comes together, it is called a joint. We are able to make a movement because the present of joints which are designed to allow movement and to assimilate shock from the movement such as running or walking. Furthermore, cartilage is an elastic and though tissue that covered the ends of the bones. The capsule act as protection centre which joints is surrounded by it. A type of tissue called synovium produces synovial fluid lined the joint capsule (Magro, C., M., and Crowson, A., N., 2003). The fluid is clear in substances that help the cartilage and bones inside the joint capsule easily lubricated and nourished. The disease process leading to rheumatoid arthritis begins here. The protective sac consists of lubricating liquid known as synovial fluid. Other than to cushioning joints, cartilage is a slippery tissue located at the ends of the bones also get nutrients and oxygen which is supplied by the fluids. Cartilage also is the structural protein in the body, which is composed primarily of collagen. The functions of this cartilage is form a mesh to give protection and flexibility to the joints. In rheumatoid arthritis, continuous inflammation of the synovium is occurred caused by an abnormal immune system response that secrete destructive molecules (Paleolog, 2002). As a result, collagen dramatically destroyed thus make the joint space

Rheumatoid arthritis (RA) is an autoimmune disease where the body’s immune system protects the body’s health by attacking unknown substances like bacteria and viruses, and mistakenly attacks the body’s joints. This creates inflammation causing the tissue that lines the inside of joints to thicken, which results in swelling and pain in and around the joints. The tissue makes a fluid that lubricates joints and helps them move smoothly. If inflammation goes unchecked, it can damage cartilage, the elastic tissue that covers the ends of bones in a joint, as well as the bones themselves. Over time, there is loss of cartilage, and the joint spacing between bones may become smaller. Joints can become

Meniscus is a piece of cartilage in the joint space where two bones meet. They are found between the ends of upper and lower leg bones in the knee. They absorb the shock and protect the joint surface from activities like running, walking and jumping. The menisci are mainly composed of type I collagen which supports the meniscal structure. Type I collagen is the main difference between menisci and articular cartilage which is composed of type II collagen. Another component of menisci is fibrochondrocytes intermixed with extracellular matrix. These fibrochondrocytes synthesize and maintain collagen and exhibit properties of chondrocytes and fibroblast. There are three layers of collagen fibers arranged to convert compressive loads into circumferential or stresses. The fibers run radially serve to resist splitting or shearing in the superficial layer where as they run parallel to resist stress during weight bearing in the middle layer. In the deep layer, they are aligned parallel to the

Unlike the knee, the articular cartilage of the ankle is uniform in thickness, measuring from 1 to 1.7mm, and displays much higher compressive stiffness than hip or knee cartilage (10,11,19,20). Ankle cartilage may develop fissures attributable to wear; this conditions does not progress to OA as it wound in the knee or hip (10,11,19, 20). Ankle cartilage also does not decrease in tensile strength with age (10,11,19-21). Compared to the hip and knee, ankle chondrocytes have different biomechanical and biologic factors to resist degradation, especially inflammatory markers. Ankle chondrocytes have decreased sensitivity to Interleukin-1 (IL-1) and matrix metalloproteinases (MMP), in particular MMP-8 that is usually elevated in OA (10,11,19, 20, 22). As a result, the ankle joint is unlikely to succumb to damage by inflammatory changes

Osteoarthritis is a type of arthritis in the knee that is most common to receive. This is a joint disease that mostly affects the cartilage. This arthritis only affects the joints. The cartilage is a slippery tissue that cover the ends of the bones in a joint. It is known as a wear and tear type of arthritis that occurs in people over the age of 50. However, it can occur to people younger than the age of 50 too. For this type of arthritis the top layer of the cartilage breaks down, which causes the slippery tissue to wear away. What happens then is that the bones of the joints rub closely against each other with less of the cartilage.