Malignancies of the nasal cavity and paranasal sinuses constitute fewer than 1% of all malignancies and 3% of upper aerodigestive tract malignancies. [1] The majority of these tumors are in the maxillary sinus, and squamous cell carcinoma is the commonest histological type [2]. Mucoepidermoid carcinoma (MEC) arising from mucous glands of maxillary sinus are extremely rare and accounts for 13% of all malignancies, [1] Kraus et al, in his study of 49 patients with non squamous tumours of maxillary sinus reported sarcomas, adenoid cystic carcinomas, lymphoma and adenocarcinoma accounting for most of their cases. [3] Sinonasal malignancies occur twice as often in males as in females, and are most often diagnosed in patients 50 to 70 years of age. [4] …show more content…
[5] This type of carcinomas once been regarded as benign lesions , called mucoepidermoid tumour later, WHO(1990) recommended as mucoepidermoid carcinoma Stewart et al (1945) was the first to describe as MEC is a separate pathological entity. [6] Peak age of occurrence of mec is older age with mean of 44.5 years. [7] MEC tumours occur in major salivary glands [53%] ; parotid gland [45%] followed by the minor salivary glands of the palate [25%]. [5] Histologically, MEC is classified into three types of malignancy-low, intermediate, and high grade using five histopathological features namely intracystic component, neural invasion, necrosis, mitosis and anaplasia. [5] The main therapeutic method in the treatment of MEC, like in most types of salivary gland malignancies, is surgical resection and post-operative radiotherapy seem to be efficient. [7] As MEC is a rare carcinoma among all, no risk factors are known, long term outcome of the data are difficult to diagnose. We report a rare case of mucoepidermoid carcinoma of maxillary sinus in a 16-year-old female with clear cell
Mucosal Melanoma: this transpires in any parts of the mucous membrane in the body. For example the bodies nasal passages & the throat.
J.H. s is a 78 y.o. male with a history of moderately differentiated SCC of the left mandible. This was diagnosed in October 2013. There was some delay on the patient’s behalf on scheduling the surgery. He then had a sync opal episode and was found to have severe bradycardia and junctional bradycardia. He underwent a CABG X4 for 3 vessel disease and pacemaker placement on 11/10/2013. He underwent a left marginal mandibulectomy and left neck dissections of level 1-4 on 01/23/2014. Pathology reported grade 2 moderately differentiated SCC nodes were positive. Patient declined adjuvant therapy. Patient did well until June when he developed an infection in the hardware. He was taken back to surgery 02/10/2014 for removal of hardware and biopsy of the left cheek and mass, which was found to be invasive cancer. He then agreed to radiation and chemotherapy, which has since started. Since he develop issues with dysphagia during therapy, and a peg tube placement was recommended. He underwent a successful placement of a peg tube on 4/05/14.
Mesothelioma is a unusual form of cancer that occurs in the mesothelium (a thin layer of tissue that covers most of our internal organs.) In most cases, the tissue near the lungs is affected. However, cases have been reported in which other body organs are affected with this condition. This form of cancer is extremely aggressive and often proves deadly if it is malignant Mesothelioma.
Squamous Cell Non-Small Cell Lung Cancer (NSCLC) occurs in about 30% of all Non-Small Cell Lung Cancer cases. (Khan Academy Medicine, 2012) There are two main features of squamous cell NSCLC that distinguish it from adenocarcinoma and large cell NSCLC. Squamous cells contain keratin within the cell and are connected to each other by desmosomes (Khan Academy Medicine, 2012). Squamous cell NSCLC is most commonly found in male smokers who have a cough, airway obstruction, Hilar-adenopathy, mediastinal widening with chest x-rays, and Hypercalcemia (Harold, J. Bruyere, 2009).
Carcinomas- glands, organs and tissues, arise from epithelial cell lining external and internal body surfaces; most common cancer
Squamous carcinomas are flat cells that form inside the airways. It is usually linked to smoking. Large cell carcinomas can grow in any area of the lung. It usually grows fast and spreads rapidly.
Reaching out to the American Cancer Society, as well as nurse practitioner Mary Hesdorffer. I become knowledgeable on the diagnosis of Mesothelioma. Mesothelioma comprises 3% of cancer diagnosis. It develops in the mesothelial cells in one’s body; cells that are protective lining for the body’s organs and cavities. The disease has five known forms. Four of the forms are malignant cancers, with one being benign. Malignant cancer grows and invades the surrounding tissues, were benign cancer does neither. Pleural Mesothelioma develops in the lining of the lungs, known as the pleura with 70% of diagnosis being this form. Peritoneal Mesothelioma develops in the lining of the abdominal cavity, known as the peritoneal membrane with 25% of diagnosis being this form. Pericardial Mesothelioma develops in the lining of the heart, known as the pericardium, with 5% of cases being pericardial. Testicular Mesothelioma develops in the tunica vaginalis of the testicles, being the most rare form with fewer than 100 documented cases. Benign Mesothelioma, only form were full recovery is the probable outcome, is a form of mesothelioma that develops in the pleura, difference being its stagnant.
One specific type of cancer is called Angiosarcomas, or cancer of the endothelial cells. This is a rare, and very serious form of cancer. This type of cancer occurs in the head and neck region, and it usually appears in the scalp of the elderly. Occasionally
April 20th 2011 was the date of the discovery. A cause of SCC is associated with Human papilloma virus, with the oropharynx, lung, fingers, and anogenital region. Exposure to sunlight could also be another cause to SCC, you have to have protection on your skin. With this kind of exposure it is the strongest environmental risk factor. Squamous Cell cancers of the lip and ears are high rates of recurrence and distant metastasis. Individuals on immunotherapy or suffering from lymph proliferative disorders(leukemia) tend to be much more aggressive, regardless of the location. The symptoms might have are highly variable depending on the organ it is on. Lesion caused by SCC is often asymptomatic. Reddish skin blotches that are slowly growing is another sign. If the tumor continuously bleeds especially on the lip, that is another symptom you could look for. Usually the tumor shows as an ulcerated lesion with hard raised edges. Also your tumor grows relatively slowly. A way for SCC to be treated is by surgery. If the doctor diagnoses the cancer they will quickly take you to get it removed. It is almost always curable and it causes minimal damage. But if it
A 68-year-old man complained of a laryngeal invasion due to a neck mass and underwent a wide excision of the thyroid bed and a complete laryngectomy. The patient was initially diagnosed with a sarcomatoid carcinoma of the neck, which showed a rather unusual histological profile. The tumor showed epithelioid-tubular structures containing mucin pools, with a fibrous or sarcomatous background, which is not consistent with the typical morphological features of ATC (Fig. 1A and 1B). The patient was treated with adjuvant radiotherapy (42 Gy) and chemotherapy, with the regimens adjusted for sarcomatoid carcinoma of the larynx (2 cycles of etoposide, ifosfamide and cisplatin, and 2 cycles of ifosfamide and adriamycin). However, the size of
Nevertheless, the low prevalence of sinonasal malignancy is supplemented by a great diversity of neoplasms that may arise in the anatomically complex region. Further, the rarity and peculiar features of some of these neoplasms lends itself to a greater risk of misdiagnosis 1. For these reasons, sinonasal malignancies remain a challenging area for pathologists and head and neck surgeons alike. Human papillomavirus (HPV)-related carcinoma with adenoid cystic-like features is a relatively recently described type of sinonasal carcinoma related to HPV. This subtype has morphologic overlap with basaloid squamous cell carcinoma, it, however, can be distinguished by absence of squamous differentiation, surface level epithelial dysplasia, as well as a significant ductal component on histologic analysis. In this case series we present two patients with HPV-related carcinoma with adenoid cystic-like
It was slowly progressive and painless with no other significant present or past history.Examination revealed 2x3 cm circumscribed mucosal covered swelling on the right lateral border of mobile tongue,which was firm in consistency and non tender as shown in figure 1 below.Base of tongue, floor of mouth, retromolar trigone were free from swelling and apparantly normal.No restriction of tongue movements was seen nor was any cervical lymphadenopathy felt.All the blood investigations were normal.Fnac of the swelling was asked which showed it to be benign mesenchymal lesion possibly neurogenic tumor.Patient was prepared for surgery after proper metastatic work up.Tumor was excised perorally enmass as shown in figure 2 , and sent for histopathological examination which revealed the of presence of elongated tumor cells arranged in eosinophilic cords and compact oviod bodies( verocay bodies) with palisading confirming the diagnosis of Schwannoma of
A total of 1855 biopsy specimens were accessioned at our biopsy services during the study period (2002 – 2006). In this period, 37 cases were salivary gland neoplasms accounting to 1.99% of all biopsy specimens accessioned. Of 37 cases, 11 were benign neoplasms (29.72%) and 26 were malignant (70.27%). The common tumors overall was Pleomorphic adenoma (PA) and Muco-epidermoid carcinoma (MEC) (Table 1).
Tumors are one of the most feared diseases of our time. Many people upon hearing the word “tumor” immediately resonate to the conclusion of it being cancer, which is not necessarily true. Tumors fall into to two main types, benign and malignant. Although they are considerably different in tissue invasion, their nature that makes them distinct and symptoms, they are also quite similar in the way they recur in the same location, growth size and their health risks.
Importance of careful assessment of oral cavity for suspicious lesions for early detection of multiple myeloma.1