Myeloma Case Study

MM is often also characterized usually in the pelvis, spine, ribs, and skull by diffuse osteoporosis.

In September 2015, Mr. C was re-diagnosed with multiple myeloma, which had been in remission for 4 years, and he is currently receiving cancer chemotherapy. Mr. C reported that the cancer is more debilitating this time around as he is experiencing more pain, only sleeps three to four hours a night, and has noticed a dramatic decrease in energy over the last month. This decrease in energy particularly upsets him because he reports not having the energy to spend time with his girlfriend and her son.

The claimant is a 48-year-old male who fell off a ladder while working and fell 15 feet backward striking his head, sustaining an acute right subdural hematoma, multiple rib fractures, and left-sided nondisplaced clavicle fracture. He was admitted to the hospital on 11/27/2017 and was discharged to home on 12/05/2017.

Multiple Myeloma is a neoplastic disease that involves the plasma cells within bone marrow. Plasma cells are a type of white blood cell that helps make up our immune system. They work within our immune system by generating antibodies that guard us from microorganisms and other unsafe materials. Although multiple myeloma forms in the immune system, the abnormal antibodies decrease the effectiveness of the body ability to fight infection. Since multiple myeloma is an uncommon cancer, the etiology is idiopathic, unknown. When plasma cells start to divide rapidly they become abnormal, and this is when myeloma starts. Healthy patients have a 5%

Multiple myeloma (MM) is characterized by neoplastic proliferation of immunoglobulin-producing plasma cells. Many malignancies can mimic MM, however the concomitant existence of another primary malignancy alongside MM is exceedingly rare. We report the first case wherein MM and esophageal adenocarcinoma manifest concomitantly.

Leukemia, Hodgkin lymphoma and myeloma are all types of blood cancer affecting the white blood cells, namely lymphoid or myeloid white blood cells or the plasma cells. In one research conducted in the Nurses’ Health Study, NHS, and Health Professionals Follow-Up Study HPFS, over a 22 years period, they found association between consuming aspartame and increased risk of the blood cancer. A large sample consisting of 77,218 women aged between 30-55 years old and 47,810 men within an age group of 40-75 years was taken. The average consumption of aspartame was calculated to be 114mg in HPFS and 102 mg in NHS. The results of the study prevailed a positive correlation between consuming diet soda and risk of non-Hodgkin lymphoma and myeloma in men only. However, the risk ok leukemia increased for both men and women. (Schernhammer et.al. 2012) These results were examined and concluded with the reasoning of aspartame being a methyl ester which is broken down into toxic products inside our body. In another study, these products

Calcium modifications are the results of to low or to high calcium levels. When calcium levels are to low compromises in bone integrity will occur. Adults 50 years of age and older are encouraged to increase calcium intake to help prevent osteoporosis. Patients with thyroid dysfunctions may experience low hormone levels causing low calcium secretion. Kidney disease, liver disease and pancreatitis also decrease the calcium level due to the effects of absorptions of vitamins and minerals in the body. Patients that have a calcium deficiency are encouraged to

In Boston, Massachusetts, small groups of families sued US companies due to the constant leukemia and health deaths, caused by the poisonous chemicals dumped in the water, which got flowed into the communities water supply. Anne Anderson discovered that her child had leukemia. Searching for the cause, its discovered that there's a cluster of children with leukemia. Anderson, as well as the other families affected by the water, evolve into a law suit against two large companies.

There are several ways to treat Myelodysplastic Syndromes. The plan of action of one’s treatment depends on the severity of the syndrome and age. Types of standard treatment are supportive care, drug therapy, and chemotherapy with stem cell transplant. Supportive care is used to reduce problems or side effects associated with the syndrome or its treatment. One supportive care option is blood transfusion. Transfusions can be specific to the type of cytopenias. For example, if a patient is experiencing anemia, a red blood cell transfusion is given. Platelet transfusions are given when a patient is bleeding easily, platelet count is low, or when the patient is having a procedure that may cause bleeding. Patients can also receive transfusions to

Stage I: Patients with myeloma “stage 1” don't show any symptoms because there are not that many cancer cells in the body. If myeloma has interacted with the kidney function, the effect may be considerable worse than of the stage where it is at. Characteristics of stage 1 include the following:

Acquired chromosomal abnormalities are considered as an important prognostic marker in several hematologic malignancies. Cytogenetic aberrations play an important role in pathogenesis of disease and survival outcome. Here, our goal is to study the prognostic impact of Myc abnormalities and their role in progression of multiple myeloma. The study will also include cyclinD1 gene rearrangement; the most common translocation observed in MM. We will analyze how the presence and absence of cyclinD1 oncogene affect the role of MYC oncogene on MM and vice versa. From xx/xx/xx to xx/xx/xx, we identified 87 myc positive cases, 137 CyclinD1 positive cases and 27 cases that involve both abnormalities. We hypothesize that cyclin D1deregulation has better survival advantage than MYC

Multiple Myeloma (MM) is a plasma cell disorder characterized by the neoplastic proliferation of plasma cells in the bone marrow producing monoclonal immunoglobulins. We present a case of light chain lambda predominant MM resulting in acute kidney injury necessitating long term hemodialysis.

Myeloproliferative disorders (MPDs) are groups of disorders that affect the hematopoietic stem cell. In 1951 , William Dameshek categorized the classical myeloproliferative disorders rely on clinical symptoms and morphological features, which include chronic myeloid leukemia (CML), Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) (Dameshek,1951; Tefferi 2008). In 2008, the World Health Organization (WHO) described the disorders as myeloproliferative neoplasms (MPNs) and classified them based on Philadelphia chromosome/BCR-ABL1 fusion gene. The CML associated with Philadelphia chromosome, PMF, ET, and PV are called classic BCR-ABL1-negative MPNs (WHO classification2008). Additionally, the WHO classified MPNs based on the presence of MPL mutations and JAK2 (Swerdlow et al., 2008).

Advancement in healthcare and pharmaceutical sciences has risen life expectancy and the number of old people. It has been predicted that by 2050, there would be about 380 million people in the world that are over the age of 80 (Luliano, 2014). Understanding the nutritional health of these people and ensuring that all vital minerals, such as iron and calcium are being consumed at required amounts is an important activity as with increased age, the risk of diseases, both nutrition and non-nutrition related, increase progressively (Luliano, 2014). Calcium is one of the most significant nutrients required by all human beings and the National Institutes of Health (2015) recommends that men and women, over the age of 50 need about 1000-1200mg of calcium per day. Calcium deficiency, either due to poor diet or due to the use of medications for some diseases like cancer, seriously affects bone health and increase risk to fractures and osteoporosis (Warensjo et al., 2011).

S.L. is a 34-year-old male that arrived at his primary care provider’s office today for what he states is his fourth “cold” this year. He proclaims that he has been coughing non-stop and feels congested. He denies taking his temperature but has felt occasional sweats and chills. This being his fourth visit to his primary care provider for the same signs and symptoms. At the previous visits, he was diagnosed with upper respiratory infections that only antibiotics such as amxocillin seem to clear up. Other medical management he has tried has been acetaminophen for