Neuromuscular Junction Case Study

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Introduction The neuromuscular junction (NMJ) is a specialized communication synaptic area where an electrical nerve impulse is converted into an electrical stimulation, and once this process is executed, a muscle contraction is generated (Boron, Boulpaep, & Mocydiowski, 2012, p. 216). Lamentably, there are autoimmune disorders that disrupt the function of the NMJ leading to various neuromuscular disorders. In this midterm assignment, I will be presenting a rare autoimmune disease that alters the function of the NMJ resulting in a condition known as Myasthenia Gravis (MG). MG is an incessant autoimmune neuromuscular disease identified by fluctuating periods of a weakness of the skeletal muscles of the body. The National Institute of Neurological…show more content…
Nonetheless, Angelini (2011, p. 5) illustrated the following physical and laboratory testing to solidify the diagnosis of MG: First is pharmacological testing using a drug Edrophonium which is an acetylcholinesterase inhibitor that improves MG related weakness, followed by serological testing to check the presence of antibody associated with MG (Seronegative or seropositive MG), followed by electrophysiological testing to assay the muscle depolarization response, for MG patient's, this reaction is altered and reduced. And finally, using an imaging studies. As indicated by Sathasivam (2014, p. 10), all MG patients will need an imaging studies of the thorax to investigate for thymoma (tumor of the thymus gland) or thymic hyperplasia. Furthermore, the researcher suggested that imaging of the mediastinum should be reassessed in the setting of an MG deterioration following a period of dormancy of the disease since the possibility of thymoma may occur near the latter part of the condition. Nasseri & Eftekhari (2010, p. 413) describes the appearances of thymus on various imaging modalities. On a frontal chest x-ray of young child (Figure 1), the thymus is notably significant but difficult to see due
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