Nowadays, a large spectrum of the studies focus on nanoparticles. Silver nanoparticles (Ag-NPs)

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Nowadays, a large spectrum of the studies focus on nanoparticles. Silver nanoparticles (Ag-NPs) have a lot of application in many aspect from medicine and biotechnology to industry. Despite of the increasing studies on Ag-NPs, the mechanism, associated to their effects, especially probable toxicity on reproduction procedure, developmental process and offspring behavioral following this period, are not so clear. Therefore in the present study the effect of Ag-NPs exposure during gestational period on offspring's depression behavior was assessed. Thirty virgin female mice were divided into three groups (n= 10 for each group) including: one control and two experimental groups which one received low dose (0.2mg/kg) and the other received high…show more content…
Increasing application of Ag-NPs has increased its environmental exposure. Nanomaterials have some neuro-toxicity including short-term memory reduction and learning ability decreasing[6]. Also, it was reported that the prenatal exposure to nanoparticles can effects on neurobehavioral development[7] via ROS augmentation in hippocampus[8]. In particular, females are more prone to nanoparticle diverse effects as their toxicity may lead to impairment of reproductively and fetal development[9]. Ag-NPs, in perticular, can pass blood brain barrier (BBB) so, they can accumulate in the brain[10]. Also it was shown that even in low concentration, silver has long maintenance time in brain than the other tissues[11]. Furthermore, Ag-NPs retention time in mouse body was more than 4 months. These findings provide enough time for Ag-NPs to affect on neural cells natural physiology and development. It was recorded that Ag-NPs pass from placenta, as a vital barrier, so it causes neurotoxicity in the fetus[12], [13]. Also some studies reported that Ag-NPs are accumulated in fetuses tissues by passing from placenta[14]. But still little information is available associated to the relation between prenatal Ag-NPs exposure and following behavioral performance. Various application in medicine, passage from the placenta and following that passing from the BBB, long maintaining and long retention time come to consideration this

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