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The Effects Of Sleep Deprivation On Insulin Resistance And Type 2 Diabetes

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The Effects of Sleep Deprivation on Insulin Resistance and Type 2 Diabetes
A Meta-Analysis
Dalal Mazraeh
Saint James School of Medicine
Preceptor: Maja Delibasic, M.D.

ABSTRACT
Sleep deprivation and sleep restriction leads to insulin resistance and the development of type 2 diabetes. To study whether shortened sleep and sleep deprivation affects insulin resistance and glucose intolerance, we developed a meta-analysis of 7 studies that research this topic. The studies included had 92,176 men and women participants with no previous diagnoses of diabetes, with follow-up range of 2-15 years. Of the total participants, 3,206 cases of type 2 diabetes were reported in the follow up period . In pooled analyses, sleep deprivation showed a significant relationship to increased insulin resistance and development of type 2 diabetes. The follow-up period also showed a progressive increase in diabetes. For short duration of sleep (≤5–6 h/night), the RR was 1.66 (95% CI 1.54-1.78, P = 0.001 and heterogeneity P = 0.012). Sleep deprivation may be a significant and an independent factor that may lead to insulin resistance, glucose intolerance and symptomatic diabetes.

INTRODUCTION
It has been scientifically proven that sleep is a crucial biological task that our body performs to maintain optimal functional capacity(Xu, Q. 2010). According to data collected by National sleep foundation short sleep deprivation is linked with many side effects, such as, increased risk of

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