The Role Of Micrornas In Cancer

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The general characteristics of tumor include the increased proliferation rate and migration ability, the loss of cellular identity and the failure of controlling the cellular death. How is miRNA involved in the development of cancer? Kolokythas et al. considered it was possible that the involvement of miRNA in cancer merely reflected the loss of normal cellular characteristics during malignant transformation [21]. Furthermore, microRNAs have also been documented to have roles in all of the cancer hallmarks defined by Hanahan and Weinberg in 2011[18-13].
MicroRNAs in cancer could act as oncogenes or tumor suppressor genes. They down-regulate tumor suppressor genes when functioning as oncogenes, on the contrary, by down-regulating oncogenes,

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