INTRODUCTION
Type 1 diabetes mellitus (T1DM) is the most common metabolic disorder in which both genetic and environmental factors are involved [1]. T1DM is considered a chronic immune-mediated disorder. It was hypothesized that whilst children have a genetic predisposition to T1DM, there is likely to be an environmental factor that triggers the development of T1DM. Possible triggers that have been suggested include viral infection, vaccines, low levels of vitamin D and cow’s milk, [2]. Oxidative stress is one of the important pathways that have been involved in the etiopathogenesis of T1D [3]. Complications of T1DM could be due to the cellular metabolism leading to hyperglycemia and excess production of reactive oxygen species (ROS).
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Objectives
This study aimed to evaluate the association of glutathione S-transferase mu 1 (GST M1) and glutathione S-transferase theta 1 (GST T1) polymorphisms with the development of T1DM and disease- related risk factors.
PATIENTS AND METHODS
The study included 64 diabetic children with T1DM with a mean age of 11.7± 3.6 years; 26 boys and 38 girls. They were enrolled from the attendants of pediatric genetic and endocrinology unit and pediatric outpatient clinic of Menoufia university Hospitals, Egypt. The study was conducted in the period from January 2015 to March 2016. Diagnosis of T1DM patients was based on the American Diabetes Association (ADA) criteria [9]. Patients were followed up , regularly checked and investigated accordingly for diabetic complications , their current treatment regimens. Cases suffering from 2ry diabetes , or having chronic-related diseases , like hypothyroidism or hyperthyroidism or hypoadrenalism were excluded.
Forty-one apparently healthy children of matched age and sex served as a control group. Written informed consent was obtained from each child included in the study or their participant parents. Ethical clearance was obtained for the research project. The study protocol conforms to the ethical guidelines of the 1964 Declaration of Helsinki and its later amendments. Data about the duration of illness and onset of the disease in children with T1DM were taken. Body
My family and I have managed diabetes for a considerable length of time are as yet managing this ailment. My grandmother had Type 1 diabetes, my dad has Type 1 diabetes, and I have Type 2 diabetes. Diabetes is a condition where the measure of glucose in your blood is too high in light of the fact that the body can 't utilize it legitimately. This is on the grounds that your pancreas does not create any insulin, or insufficient, to offer glucose some assistance with entering your body 's phones – or the insulin that is delivered does not work legitimately. There are three principle sorts of diabetes: Type 1 diabetes, Type 2 diabetes, and Gestational diabetes. This article will manage what those sorts of diabetes are, what causes them, and
Type I Diabetes was once referred to as Juvenile Diabetes or Insulin Dependent type Diabetes Mellitus (IDDM). Type 1 diabetes, is an incurable but treatable disease which can occur at any age but is mostly found in children. Couch et al. (2008) states, “Juvenile diabetes affects about 1 in every 400-600 children and more than 13,000 are diagnosed yearly” (pg. 1). A 2014 CDC fact sheet concerning diabetes, showed that, “In adults, type 1 diabetes accounts for approximately 5% of all diagnosed cases of diabetes in the United States.” It seems that we all know someone who is affected by diabetes; either type 1 or type 2. Diabetes seems to be such a common-place illness and is much more prevalent in today’s society. However, this hasn’t always been the case. Gale (2002), states, “At the start of the 20th century, childhood diabetes was rare… (pg. 3353).” In this paper, I will provide information about Juvenile or Type I diabetes in order to educate the reader about this illness.
Diabetes mellitus is a permanent condition which alters the body's ability to take in glucose consumed in food. The most common types of diabetes are type 1 diabetes and type 2 diabetes. Both of these conditions exhibit similar characteristics; the patient’s body synthesizes the carbohydrates and sugars consumed into glucose, but the body cells cannot take in the sugar. The body uses glucose to fuel its cells, however, for this to happen it requires a hormone called insulin. This hormone facilitates the uptake and conversion of glucose into energy. Therefore, in the case of the body not producing, lacking enough, or failure to use insulin, the patient suffers diabetes mellitus. Type 1 diabetes is a genetic condition, which begins in childhood thus the name juvenile-onset. In this condition, the body attacks its pancreas making it unable to produce insulin. This type of diabetes may lead to loss of eyesight or heart disease and stroke in extreme cases. Thus, it is vital for the patient to undergo treatment that involves taking in insulin. Type 2 diabetes accounts for 95% of all diagnosed cases in adults, initially, people referred it to as adult-onset diabetes. However, over time there has been a growth of overweight and obese kids
According to American Diabetes Association, “diabetes is one of the most serious health problems that the African American community faces today. Compared to the general population, African Americans are disproportionately affected by diabetes.” With that being said I feel that diabetes is something that should be addressed. I myself have a long family history of diabetes, making myself at risk of one day having it.
Type 1 Diabetes is an autoimmune disease where the islet cells in the pancreas are killed off by the subject’s immune system. The disease is genetic and can be triggered by a cold or flu virus. The first historic evidence of type 1 diabetes was referred to as the “pissing disease,” because those who were sick would die from dehydration due to frequent urination. Insulin is a hormone that acts as a key that opens the door for cells to receive glucose. The first experiments with insulin, the hormone that the islet cells produce, was preformed by injecting the hormone from one dog’s pancreas to another dog’s bloodstream. The blood sugar of the dog receiving the insulin was lowered. When the mass production of insulin began, the manufacturers used modified bacteria to
type 1 diabetes is usually presents in childhood and young adults life , and was known as juvenile diabetes . it is mostly common in people with European decent . and it is a chronic condition in which the pancreas produces a little or no insulin ,( a hormone needed to allow sugar to produce energy) .
Type 1 diabetes mellitus is one of the most renowned health complication that affects people in their childhood stage. Its causal factor is a deficiency in the insulin levels of the human body. This deficiency in insulin is accompanied by the destruction of pancreatic beta cells. People suffering from this condition require insulin injection so that the amount of glucose levels in their bodies can be regulated to the desired levels (World Health Organization, 1999). The risk factors for diabetes have not been clearly defined but have been linked to the interaction of environmental factors and genes.
According to the U.S Department of Health and Human Services, there are 15,600 new cases of Type I Diabetes Mellitus (T1DM) each year (U.S Department of Health and Human Services, 2011). Boys and girls are at relatively equal risks for developing T1DM up until fourteen years old, with risks peaking around puberty. Following puberty, incidences tend to be higher in white males than women (Soltesz, Patterson, & Dahlquist, 2007). When looking globally by region at incidences, they tend to be higher in European countries, such as Finland, Italy, Sweden, and the United Kingdom. This could be related to the genetic susceptibility people in these areas carry around, such as a certain gene associated with the autoimmune response of T1DM
Across America there are a large number of children who wake up every morning with the challenge of navigating another day with Type 1 Diabetes. According to the Boston Children’s Hospital website, type 1 diabetes (commonly called juvenile diabetes) is “an autoimmune disease- more specifically, a disorder of carbohydrate metabolism- in which the immune system attacks and destroys the insulin-producing cells of the pancreas (called beta cells).” In this paper, we will highlight how this disease affects many aspects of their daily lives as well as their interpersonal relationships. Type 1 diabetes affects all types of children from various backgrounds. There are risk factors involved, current investigations into treatment taking place,
Type 1 diabetes (T1D), also known as insulin-dependent diabetes, is a metabolic disorder in which the pancreas either does not produce enough or stops the production of a hormone called insulin. Insulin is vital in helping to transport glucose from the bloodstream into body cells, where it is used for energy. Without enough insulin, the body is unable to function properly and produce enough energy that is required to carry out daily activities. Type 1 diabetes is treated with the use of insulin injections, and momentarily there is no cure. People with T1D have to take insulin for the rest of their lives (“Type 1 Diabetes”, 2015). Type 1 diabetes usually affects children and young adults, but the disorder can appear at any age. Approximately 1 in 800 or 0.12% or 340,000 people in the United States are diagnosed with T1D. About 30,000 people are diagnosed with T1D annually (“Type 1 Diabetes”, 2015). Type 1 Diabetes occurs equally in males and females, but it is more prevalent in whites than nonwhites (“Type 1 Diabetes”, 2015). Diabetes is usually easy to control with proper medical attention; however, people with diabetes may be at risk for long-term complications.
Before the increased incidence of diabetes occurred, early childhood was an extremely dangerous period of life and many deaths occurred during this period. Almost a third of all neonates failed to make it to their fifth birthday and most of these deaths were due to infectious diseases, which resulted in an intense evolutionary pressure. Children who were most likely to make it to their fifth birthday were those who could develop a versatile immune system in a short period of time. Many children got sick during this time period, and because of the lack of access to medicine and healthcare standards at the time, most did not survive. This changed as the 1900s hit and treatments were developed and sanitation methods began to increase.
Diabetes is a heterogeneous group of metabolic diseases characterised by high levels of blood glucose (hyperglycaemia) due to defects in the β cell function in the pancreas which is impacting the insulin secretion or insulin action, resulting in the inability to self-regulate the levels of blood glucose in the body (Stumvoll et al.,2005). Short term symptoms of hyperglycaemia include: polyuria , polydipsia, blurred vision, however the chronic effects of hyperglycaemia are associated with long term organ dysfunction and damage, especially the blood vessels, retina in the eye, kidneys and heart (Uazman et al., 2014). Diabetes has become a world-wide concern due to its high prevalence in the world (in 2015, 415 million of people were estimated
Diabetes is a chronic disease which can be described according to its causes, symptoms and types. Diabetes is a chronic situation that affects the human body's capability to use insulin. Insulin is a hormone that directs the level of sugar in the blood. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), diabetes affects 25.8 million people. The causes of diabetes are diverse. However, genetic susceptibility and environmental factors are one of causes. Heredity has critical impact in figuring out why should likely create type 1 diabetes. Environmental factors, such as foods, viruses, and toxins, may play a role in the development of type 1 diabetes . Symptoms of diabetes vary from one person to
Diabetes is a disease in which the body’s ability to produce insulin is impaired, resulting in abnormal metabolism of carbohydrates and elevated levels of glucose in the blood and urine. Glucose comes for food we eat, there are over 30.3 million people have diabetes form that 9.4% of the U.S. population. 23.1 million people are diagnosed and 7.2 million are still undiagnosed. There are three different kinds of diabetes, type 1, type 2, gestational diabetes.
Living with diabetes means tracking blood sugar levels, eating healthy, exercising and injecting insulin if the body no longer produces it on its own. With proper care, people with diabetes can live normal, healthy lives.