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Type 2 Diabetes Mellitus: A Case Study

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Background and Significance: The prevalence of type II diabetes mellitus is increasing in the United States (U.S.) and was estimated to affect 29.1 million Americans in 2012. By the year 2050, it is estimated that one in three U.S. adults will have type II diabetes mellitus. Long-term complications of type II diabetes mellitus include increased morbidity and mortality as a result of macrovascular and microvascular complications such as diabetic nephropathy, retinopathy, neuropathy, and cardiovascular disease. Several factors including genetics, insulin resistance, and decreased β cell mass can lead to the development of type II diabetes mellitus. Nonetheless, interventions that target the early stages of its pathogenesis (i.e. pre-diabetes) …show more content…

Eggs are rich source of important nutrients including proteins, vitamins, e.g. A, E, and B12, minerals, carotenoids, and lecithin. Although there are studies that have demonstrated the ability of egg consumption to improve glycemic control, insulin sensitivity, and lipid profile, there is a lack of such studies in pre-diabetes as well as early stages of type II diabetes and hence is the reason for this dissertation project. The progression of diabetes is associated with increased in oxidative stress. Oxidative stress has been shown to be attenuated by high density lipoprotein (HDL) levels, which has been shown to be increased by egg consumption. Additionally, HDL is also important in maintaining normal β-cell function and insulin secretion. Through the action of apolipoprotein (apo) A1 (ApoA1), HDL has been shown to reduce plasma glucose levels by inducing phosphorylation of AMP activated protein …show more content…

There were no significant differences in the HDL-C levels between the two groups; however, egg group tended to have higher HDL values compared to the control. Furthermore, analysis of ABCA1 protein showed that in the egg group this protein was significantly higher at the 6-week visit (0.78±0.21 mg/dL vs 0.28±0.05, P=0.0) and tended to be higher at the final visit (0.62±0.11 vs 0.55±0.18, P= 0.1). TC levels were generally higher in the egg group compared to the control; however, consumption of one egg per day did not have any adverse effects on TC during the course of study. As for the apoA1 levels, it was shown that at baseline and final visits this value was significantly higher in the egg group compared to the control (162.67±5.88 vs 147.43±5.20, P=0.06 and 147.43±5.34 vs 142.81±5.09, P=0.01, respectively). Discussion: The findings of this study suggests that daily consumption of eggs may improve factors associated with glycemic control and lipid profile in pre- and type

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