Types And Mechanisms Of Treat Drug Resistant Pathogens

people get infected with antibiotic resistant bacteria and 23,000 die each year as a result (CDC). The picture is grimmer in the developing world. This project was initiated to study a new avenue in the search of novel antimicrobials against bacteria. In order to identify potential antimicrobials, we focused our attention to Pseudomonas aeruginosa (P. aeruginosa). It is a pathogenic species of bacteria that causes a broad spectrum of infections, which are resistant to most conventional antibiotics

efficient mechanisms to acquire these transition metals, especially when confined in a human host. The human host carries an abundant amount of metals that can be harnessed by invading pathogens. To hinder a bacterium’s exploitation of these metals, the human host employs a variety of techniques collectively termed “nutritional immunity” (10). For instance, calprotectin (CP) in the host chelates intracellular stores of manganese (Mn) and zinc (Zn) to inhibit bacterial growth [5]. All pathogens require

when the proliferation of antibiotic resistance bacteria became evident as Fleming predicted earlier. With the rapid development of infectious disease associated with antibiotic resistance forced us to change the way we view disease and the way we treat patients. However, antibiotic use has not been without consequence and several factors had contributed to the development of resistance. Some resistances are due to spontaneous mutation and these mutations are for select antibiotic resistance

This essay will explore the factors responsible for infectious disease; what it is, how it is spread, and what measures can be taken to prevent it. Microbes are single-cell organisms which are so small they can’t be seen with the unaided eye; but instead with a microscope. They are so minute that millions can fit onto the eye of a needle. Microbes date back billions of years and are the oldest form of life on this earth. They come in many forms: fungi, bacteria and viruses, and can live individually

2000). Antibiotic resistance is the result of very strong bacteria or microbes that are resistant to the antibiotic prescribed and those microbes accumulate overtime by their survival, reproduction and transfer, leading to increased levels of antibiotic resistance. I have chosen this topic due to the controversies of using antibiotics due to antibiotic resistance.

They compose almost 50% of the living biomass. In order to survive, microorganisms have developed different mechanisms that enable them to respond to selective pressure applied by environment and different challenge. For example; microorganisms that cause diseases for human have developed resistance mechanism to fight antimicrobial agents. (Byarugaba.D.K.,2009) Antibiotics are drugs used for fighting infectious diseases caused by bacteria. In the last 60 years, antibiotics have become

Novel chemotherapeutic agent: • “Chemotherapeutic agents” are the drug which used to inhibit or kill microorganisms without affecting host body cells. Cancer chemotherapeutic agents New Drugs for Breast Cancer Treatment: 1. Herceptin:  Type of drug: Monoclonal antibody A class of drugs developed to work alone or together with chemotherapy to seek out and attack specific cancer cells.  Mechanism: Herceptin attaches itself to a protein called HER2 that is found on the surface of 20 to 25 percent

resistance to drugs is the result of changes in society and the microorganisms themselves (Cohen, 2000). The employment of drugs to prevent and combat disease often leads to drug resistance, as determined in the current antibiotic crisis. New ways of combating disease will and are being set up, such as the new budding theory of cross-reacting immunisation in bacterial infections. The primary weakness with this theory is that as a newfangled concept, its own complications will likely unfold. Pathogens are the

lack thereof. This source is reliable as the author is a physician himself who has experience with antibiotic resistance. This source acknowledges the fact that antibiotics may be a cure of the past and that new measures need to be taken in order to treat illnesses. As the source is a recent one, it highlights the current situation with regard to antibiotic resistance and possible future research areas. The editorial was useful to my research as it explains the effects which the overuse of antibiotics

However, P. aeruginosa is the archetypal pathogen infecting the CF lungs since approximately 80% of adult CF patients are chronically infected with this bacteria1. P. aeruginosa is a ubiquitous Gram-negative bacterium that thrives in moist environmental reservoirs such as in the soil, water and plants8, 9. P. aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals, lending to its association with life-threatening