Types And Mechanisms Of Treat Drug Resistant Pathogens

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Lipopeptides as Antimicrobials: Applications and mechanisms to Treat Drug Resistant Pathogens.

Alex Harris


First Draft
Cell Biology
CELL 7990-01
Dr. Robert Dotson
1. Abstract
A. Drug resistant pathogen diseases are increasing
B. Lipopeptides, with their amphipathic structure can target cell membrane
C. Used currently as antibiotics and antifungals.
i. Similar mechanisms of action for antibiotic properties ii. Separate similar mechanisms for antifungal properties
D. This paper describes their development, mechanisms, and applications in medicine.
2. Introduction
A. Global Impact
Over the past century, global demands for new medicines and materials have increased.
Recently, many antimicrobial resistant organisms have emerged. These microbes have become less treatable with current medications and make it difficult to prevent or treat infections in patients. Higher doses of medicine are used, but may lead to drastic side effects. Staphylococcus aureus has recently developed resistances to multiple drugs, including penicillin, methicillin, tetracyclin, and even vancomycin. The World Health Organization reported in April 2014 that drug resistant microorganisms are “…no longer a prediction for the future, it is happening right now…” New drugs are required to treat patients with these drug resistant infections.

1. Chemical cleanup
2. Renewable resources are an advantage ii. Use as antimicrobial
1. Novel antibiotics discovered at a high rate in

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