The Production Of Named Antibiotic Essay

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REVIEW THE PRODUCTION OF NAMED ANTIBIOTIC, NOTING BIOTECHNOLOGICAL INNOVATION THAT IMPROVE ASPECTS OF THE PROCESS

Introduction
Platensimycin (PTM), a metabolite of Streptomyces platensis, is an exceptional example of a distinctive structural class of natural antibiotics and have been shown to be a breakthrough in current antibiotic research due to its characteristic functional pattern and important antibacterial activity. PTM mode of action is not exploited by current drugs which makes it an important antibiotic lead against antibiotic resistance. PTM is a potent and selective inhibitors of bacterial fatty acid synthesis and targets β-ketoacyl-acyl carrier protein (ACP) synthase I/II, FabF/B elongation. It has a potent broad-spectrum Gram-positive activity in vitro and exhibits no cross-resistance to other key antibiotic-resistance bacteria including Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus, vancomycin-resistantEnterococci and linezolid-resistant, macrolide-resistant pathogens and demonstrates no cross-resistance with other antibiotics. Plantensimycin proved effective in clearing methicillin-resistant S. aureus infection from a mouse model in vitro although the high doses and suboptimal delivery system require further modification of its structure before conducting clinical trials.

Improved production of PTM or PTN by inactivating the pathway-specific transcriptional repressor gene ptmR1. Among them, S. platensis SB12026 gave
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