. Analysis of p53 gene mutations in human tumors shows that a large proportion of these mutations involve GC→ AT transitions origi- nating at sites of DNA methylation. Propose a model to explain pref- erential mutagenesis of this type at these sites.

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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. Analysis of p53 gene mutations in human tumors shows that a large
proportion of these mutations involve GC→ AT transitions origi-
nating at sites of DNA methylation. Propose a model to explain pref-
erential mutagenesis of this type at these sites.
Transcribed Image Text:. Analysis of p53 gene mutations in human tumors shows that a large proportion of these mutations involve GC→ AT transitions origi- nating at sites of DNA methylation. Propose a model to explain pref- erential mutagenesis of this type at these sites.
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Deamination is a removal of amino group from a molecule. In humans deamination occurs in the organ liver. Glutamate is also deaminated in kidneys. The deamination process involves release of ammonia from nucleotides along with another nucleotide.

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