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Explain how telomerase expression contributes to the
immortality of cancer cells
Step by step
Solved in 2 steps
- Define about this- Cancer Cells Contain GeneticDefects Affecting Genomic Stability ?Discuss how the differential gene expression is possible when all somatic cells carry identical genes and genome.Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation of a mis- match repair gene cause colon cancer?
- Some cancers are consistently associated with the deletion of a particularpart of a chromosome. Does the deleted region contain an oncogene or atumor-suppressor gene? Explain.Chromatin decompaction is a preliminary step in gene expression (Figure 29.48). How is chromatin decompacted?Explain how DNA methylation could be used to regulate gene expression in a tissue-specific way. When and where would de novo methylation occur, and when would demethylation occur? What would occur in the cells that give rise to eggs and sperm?
- n yeast cells, telomerase remains active and maintains telomeres of about 300 base pairs. Propose what would happen to the telomeres over time in a yeast lineage in which the following mutations were created. The gene encoding the catalytic subunit of the telomerase is deleted.Give typing answer with explanation and conclusion Which of the following regions of DNA would you expect to be transcribed. Select all the apply. Marks removed for incorrect selection(s) O a. Enhancer O b. 3' UTR O c. 5' UTR O d. PromoterExplain how DNA methylation can regulate gene expression in a tissue-specific way. When and where would de novo methylation occur,and when would demethylation occur? What would occur in the cellsthat give rise to eggs and sperm?