1. Devise a synthesis of the tripeptide sequence Phe Thr Lys using acid chloride below and N-methylmorpholine (NMM) for your coupling. Propose a detailed reaction mechanism for this step. You may use any readily available reagents/ protecting groups for your synthesis. In your answer you should clearly state the chosen reagents and how they are introduced and removed in your synthesis. Mechanistic details, for these steps are NOT required. Ph `NH2 „NH NH3 `NH Cor но Phe Thr Lys `NMe

1. Devise a synthesis of the tripeptide sequence Phe Thr Lys using acid chloride below and N-methylmorpholine (NMM) for your coupling. Propose a detailed reaction mechanism for this step. You may use any readily available reagents/ protecting groups for your synthesis. In your answer you should clearly state the chosen reagents and how they are introduced and removed in your synthesis. Mechanistic details, for these steps are NOT required. Ph `NH2 „NH NH3 `NH Cor но Phe Thr Lys `NMe

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 35MP

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