1a.Arrange these ligands in their order of potencies(high to low) 1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system. 1c. Which of the following has more affinity to bind to adrenergic receptors? And why? I. Epinephrine II. Isoproterenol III. Propranolol

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 6CRQ
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1a.Arrange these ligands in their order of potencies(high to low)

1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system.

1c. Which of the following has more affinity to bind to adrenergic receptors? And why?
I. Epinephrine
II. Isoproterenol
III. Propranolol

 

 

OH
Kа (им)
но
CH -CH2-NH-CH3
5
но
Epinephrine
OH
CH3
но
CH -CH2 -NH -CH
0.4
Isoproterenol
(agonist)
CH3
но
OH
CH3
о-CH2 — СH — CH2 —NH — СH
0.0046
CH3
Propranolol
(antagonist)
Transcribed Image Text:OH Kа (им) но CH -CH2-NH-CH3 5 но Epinephrine OH CH3 но CH -CH2 -NH -CH 0.4 Isoproterenol (agonist) CH3 но OH CH3 о-CH2 — СH — CH2 —NH — СH 0.0046 CH3 Propranolol (antagonist)
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