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- Show solutions. Thanks.2. Please describe the function of true activators? Please discuss the effect of ligand binding on the activity of a true activator?Moat drug act by altering the various body control systems.Name the binding site located on the surface of the cell to which drug binds to show its action with example of such drugs. Mention 2 drugs that act by inhibiting transport.
- 78. Which situation(s) might result in a higher than expected plasma drug concentration? a. Enzyme induction b. Enzyme saturation c. Competitive inhibitors of metabolizing enzymes d. A and B e. B and C1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…discuss how particle size affecting drug absorption ?
- Q3: The options for each are:- general acid-base catalysis- covalent catalysis- metal ion catalysisQ.1. We are familiar with the semipermeable nature of bio-membrane, then what types of molecules would be able to pass through them and what types of molecule would be failed to pass?42 Phosphorylation of which sight has a role in drug tolerance? Select one: a. DARPP-32 b. DAT c. CRE d. CREB
- Q2: The options to pick for each are:- general acid/base catalysis- catalysis by approximation- metal-ion catalysis- covalent catalysisIdentify which antibiotic between C and D was used per set-up. Describe each of the results by including the implications given on the graphs as to why it used Antibiotic C or D. Antibiotic C: Cationic antimicrobial peptide - these positively charged antibiotics are attracted to the negatively charged cell wall and membrane. They are hydrophobic, and they insert into the membranes to create pores. Antibiotic D: Targets lipopolysaccharide1. What physicochemical features facilitate (1) glomerular filtration, (2) drug secrecy, and (3) drug absorption in the kidney?