2. Reactivity of Carboxylic Acid Derivatives a. Rank the following carboxylic acid derivatives in order from LEAST reactive to MOST reactive when they undergo nucleophilic acyl substitution reactions. If two are close/equal in reactivity, please change the "<" to an "" sign in your ranking. `NH2 CI HO. A C E b. Justify your answer thoroughly in words. Your explanation should include, if applicable, leaving group ability, base strength, conjugate acid strengths, pKa values, etc.

2. Reactivity of Carboxylic Acid Derivatives a. Rank the following carboxylic acid derivatives in order from LEAST reactive to MOST reactive when they undergo nucleophilic acyl substitution reactions. If two are close/equal in reactivity, please change the "<" to an "" sign in your ranking. `NH2 CI HO. A C E b. Justify your answer thoroughly in words. Your explanation should include, if applicable, leaving group ability, base strength, conjugate acid strengths, pKa values, etc.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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