2. Will the following reaction occur as written? HO, NH H2N cat. H2SO4 A) Yes, after initial protonation of the carbonyl oxygen, ethanol is added to open the lactam. B) No, the lactam would dimerize under these conditions. C) Yes, cyclic amides can easily be converted to esters due to the ring strain. D) No, ring opening of the lactam does not occur since the protonation of the nitrogen occurs more readily than protonation of the carbonyl oxygen.

2. Will the following reaction occur as written? HO, NH H2N cat. H2SO4 A) Yes, after initial protonation of the carbonyl oxygen, ethanol is added to open the lactam. B) No, the lactam would dimerize under these conditions. C) Yes, cyclic amides can easily be converted to esters due to the ring strain. D) No, ring opening of the lactam does not occur since the protonation of the nitrogen occurs more readily than protonation of the carbonyl oxygen.

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 30VC

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