20. The following pedigree shows a family with an unusually high incidence of skin cancer. Examination of karyotypes from healthy, noncancerous cells in affected individuals reveals that they are heterozygous for a deletion in chromosome 12p. On the other hand, cancerous cells from the same individuals are homozygous for a deletion in chromosome 12p. What can you conclude about this form of skin cancer? a. Parents are likely transmitting a deletion of a proto-oncogene to their children b. Parents are likely transmitting a deletion of a tumor suppressor gene to their children c. Loss of heterozygosity is likely to have occurred in affected individuals d. a and b e. ba

20. The following pedigree shows a family with an unusually high incidence of skin cancer. Examination of karyotypes from healthy, noncancerous cells in affected individuals reveals that they are heterozygous for a deletion in chromosome 12p. On the other hand, cancerous cells from the same individuals are homozygous for a deletion in chromosome 12p. What can you conclude about this form of skin cancer? a. Parents are likely transmitting a deletion of a proto-oncogene to their children b. Parents are likely transmitting a deletion of a tumor suppressor gene to their children c. Loss of heterozygosity is likely to have occurred in affected individuals d. a and b e. ba

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter13: Genes, Chromosomes, And Human Genetics

Section: Chapter Questions

Problem 2TYK: The following pedigree shows the pattern of inheritance of red green color blindness in a family....

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1. Hair or fur length in cats is controlled by a single, autosomal gene; the short hair-allele is dominant to the allele for long hair. Hair color is produced by a different gene which is located on the X chromosome. One allele for this sex-linked gene produces yellow, while an alternate allele produces black fur color; individualswhich are heterozygous for these alleles are calico or tortiseshell in color.If a long-haired, black male is mated with a calico female homozygous for short hair what kind of kittens will be produced in the Ej generation? Give both genotypes and phenotypes; express the genotypes bothsymbolically and in words. Label answers clearly!!
I. In humans, chromosome 16 sometimes has a heavilystained area in the long arm near the centromere. Thisfeature can be seen through the microscope but has noeffect on the phenotype of the person carrying it.When such a “blob” exists on a particular copy ofchromosome 16, it is a constant feature of that chromosome and is inherited.A couple conceived a child, but the fetus hadmultiple abnormalities and was miscarried. When thechromosomes of the fetus were studied, it was discovered that it had three copies of chromosome 16 (it wastrisomic for chromosome 16), and that two of thethree chromosome 16s had large blobs. Bothchromosome 16 homologs in the mother lacked blobs,but the father was heterozygous for blobs. Which parent experienced nondisjunction, and in which meioticdivision did it occur?
A couple planning their family are aware that through the pastthree generations on the husband’s side a substantial numberof stillbirths have occurred and several malformed babies wereborn who died early in childhood. The wife has studied geneticsand urges her husband to visit a genetic counseling clinic,where a complete karyotype-banding analysis is performed.Although the tests show that he has a normal complement of46 chromosomes, banding analysis reveals that one memberof the chromosome 1 pair (in group A) contains an inversioncovering 70 percent of its length. The homolog of chromosome1 and all other chromosomes show the normal bandingsequence. Question: How would you explain the high incidence of paststillbirths?
A couple planning their family are aware that through the pastthree generations on the husband’s side a substantial numberof stillbirths have occurred and several malformed babies wereborn who died early in childhood. The wife has studied geneticsand urges her husband to visit a genetic counseling clinic,where a complete karyotype-banding analysis is performed.Although the tests show that he has a normal complement of46 chromosomes, banding analysis reveals that one memberof the chromosome 1 pair (in group A) contains an inversioncovering 70 percent of its length. The homolog of chromosome1 and all other chromosomes show the normal bandingsequence. Question: What can you predict about the probability of abnormality/normality of their future children?
5. A strain of Neurospora with genotype A B is crossed with a strain with the genotype a b. Half the progeny are A B and half are a b. Explain how this is possible?
1-In a pedigree analysis a family shows a possible autosomal recessive inheritance, however karyotype analysis shows a normal chromosomal pattern in all affected, can you suggest a possible explanation for this out come?
No need to explain 1.) The phenomenon in which gene present on the same chromosome remain together as gametes are produced is knows as A.) non-disjunction B.) cross-over C.) synapsis D.) linkage 2.) Queen Victoria was a carrier of hemophilia, but there is no record of the disease in any of her ancestors. It is reasonable to suggest that she became a carrier of hemophilia as a result of A.) recombination B.) a mutation C.) inbreeding D.) crossing over 3.) How many primary spermatocytes and primary Oo Yates are required to produced 100 sperm and 100 eggs? A.) 25 primary spermatocytes and 25 primary oocytes B.) 100 primary spermatocytes and 100 primary oocytes C.) 25 primary spermatocytes and 100 primary oocytes D.) 100 primary spermatocytes and 25 primary oocytes
A heterozygous pea plant produces violet flowers and yellow, round seeds. Describe the expected genotypes of the gametes produced by Mendelian inheritance. If all three genes are found on the same arm of one chromosome should a scientist predict that inheritance patterns will follow Mendelian genetics?
People with Down syndrome have an extra copy of chromosome 21, for a total of 47 chromosomes. However, in a few cases of Down syndrome, 46 chromosomes are present. This total includes two normal-looking chromosomes 21, one normal chromosome 14, and a longer-than-normal chromosome 14. Interpret this observation. How can these individuals have 46 chromosomes?
The following pedigree shows the pattern of inheritance of red green color blindness in a family. Females are shown as circles and males as squares; the squares or circles of individuals affected by the trait are filled in red. What is the chance that a son of the third-generation female indicated by the arrow will be color-blind if the father is a normal man? If the father is color-blind?
In cats, the genotype AA produces tabby fur color; Aa is also a tabby, and aa is black. Another gene at a different locus is epistatic to the gene for fur color. When present in its dominant W form (WW or Ww), this gene blocks the formation of fur color and all the offspring are white; ww individuals develop normal fur color. What fur colors, and in what proportions, would you expect from the cross AaWw Aa Ww?
Individuals affected by a condition known as polydactyly have extra fingers or toes. The following pedigree shows the pattern of inheritance of this trait in one family: From the pedigree, can you tell if polydactyly comes from a dominant or recessive allele? Is the trait sex-linked? As far as you can determine, what is the genotype of each person in the pedigree with respect to the trait?