2) We hear of a mother with 10 natural children, 8 of whom have blue eyes while the other two (one boy and one girl) have brown eyes. Both parents have blue eyes and mixed paternity has been ruled out. a. How would a geneticist explain the brown eyed children? b. Would you recommend to this mother that she and all of her children sign up for the All of Us genome project under the assumption that this large family would be particularly valuable for the GWAS part of that program? Succinctly explain your answer.

2) We hear of a mother with 10 natural children, 8 of whom have blue eyes while the other two (one boy and one girl) have brown eyes. Both parents have blue eyes and mixed paternity has been ruled out. a. How would a geneticist explain the brown eyed children? b. Would you recommend to this mother that she and all of her children sign up for the All of Us genome project under the assumption that this large family would be particularly valuable for the GWAS part of that program? Succinctly explain your answer.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter16: Reproductive Technology, Genetic Testing, And Gene Therapy

Section: Chapter Questions

Problem 9QP: Cystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites...

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2. You cross a pure-breeding red guinea pig with short hair and a pure-breeding white guinea pig with long hair. Allof the offspring are long hair and cream colored.a. What type of inheritance is hair length? Hair color? How do you know?b. What are the genotypes of the parents?c. Determine the genotypes and phenotypes and how many are expected for the F2 generation. (Just leaveyour answers as a list with numbers beside them. No ratios required.)
Two mothers give birth to sons at the same time at a busy urbanhospital. The son of mother 1 has hemophilia, a disease causedby an X-linked recessive allele. Neither parent has the disease.Mother 2 has a son without hemophilia, despite the fact thatthe father has hemophilia. Several years later, couple 1 suesthe hospital, claiming that these two newborns were swappedin the nursery following their birth. As a genetic counselor, youare called to testify. What information can you provide the juryconcerning the allegation?
A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement?
4. An albino corn snake is crossed with a normal-coloredcorn snake. The offspring are all normal-colored.When these first-generation progeny snakes arecrossed among themselves, they produce 32 normalcolored snakes and 10 albino snakes.a. How do you know that only a single gene is responsible for the color differences between these snakes? b. Which of these phenotypes is controlled by thedominant allele?c. A normal-colored female snake is involved in atestcross. This cross produces 10 normal-coloredand 11 albino offspring. What are the genotypes ofthe parents and the offspring?
A study of three generations in a family of a male colleague of the authors indicated that many of the man's blood relatives had died of cardiovascular accidents and coronary heart disease. Others died of other causes but were affected by high blood pressure. What are the implications of this information for the man in question? b. What information and help might a genetic counselor provide?
Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?
1.) A farmer wants to breed a variety of taller corn. a) How can the farmer use variation in the height of the current corn plants to produce taller corn plants? b) Will the farmer’s work be most effective if height in corn plants is determined by polygenic inheritance, multiple alleles, or co-dominant alleles? Explain. c) The farmer finds that many of the tallest corn plants are also very susceptible to a particular disease. How could the farmer design an experiment to find out if the genes for height are linked to the genes for resistance to the disease?
A young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cysticfibrosis is a recessive disease, and neither member ofthe couple nor any of their four parents is affected.)a. What is the probability that the female of thiscouple is a carrier?b. What are the chances that their child will havecystic fibrosis?c. What is the probability that their child will be acarrier of the cystic fibrosis disease allele?
2. Uniparental disomy is a rare phenomenon in whichonly one of the parents of a child with a recessivedisorder is a carrier for that trait; the other parent ishomozygous normal. By analyzing DNA polymorphisms, it is clear that the child received both mutantalleles from the carrier parent but did not receive anycopy of the gene from the other parent.a. Diagram at least two ways in which uniparentaldisomy could arise. (Hint: These mechanismsall require more than one error in cell division,explaining why uniparental disomy is so rare.)Is there any way to distinguish between thesemechanisms to explain any particular case ofuniparental disomy?
2. Uniparental disomy is a rare phenomenon in whichonly one of the parents of a child with a recessivedisorder is a carrier for that trait; the other parent ishomozygous normal. By analyzing DNA polymorphisms, it is clear that the child received both mutantalleles from the carrier parent but did not receive anycopy of the gene from the other parent.a. Diagram at least two ways in which uniparentaldisomy could arise. (Hint: These mechanismsall require more than one error in cell division,explaining why uniparental disomy is so rare.)Is there any way to distinguish between thesemechanisms to explain any particular case ofuniparental disomy?b. How might the phenomenon of uniparental disomyexplain rare cases in which girls are affected withrare X-linked recessive disorders but have unaffectedfathers, or other cases in which an X-linked recessive disorder is transmitted from father to son?c. If you were a human geneticist and believed oneof your patients had a disease syndrome caused…
A sex-linked recessive allele rg causes a red-green colorblindness in humans. A normal woman whose father was colorblind marries a colorblind man. A. What genotypes are possible for the mother of the colorblind man? B. What are the chances that the first child from this marriage will be a colorblind boy? C. Of the girls born from this union, what proportion can be expected to be colorblind? D. Of all the children of these parents
1. Fur color of rats is determined by the pathway below. The mating between brown rats of identical genotypesproduced the following offspring: 14 cream-colored, 47 Brown, and 19 albino.Gene B Gene DAlbino  Cream  Browna. What type of inheritance is this?b. What is the genotype of the two parents?c. Complete the cross described above. Identify which genotypes are brown, cream, and albino. Includethe expected phenotypic ratio (brown:cream:albino)