3. Some medications permanently inactivate their target enzyme by forming a covalent bond to an amino acid in the enzyme's active site. Aspirin is one example of a pharmaceutical that uses this type of mechanism. So is penicillin. As you saw in the last chapter, the active portion of penicillin is the B-lactam ring. Penicillin forms a covalent bond to serine in the active site of transpeptidase, an enzyme that is essential for forming the bacterial cell wall. Propose a mechanism for the inactivation of transpeptidase by penicillin and show the final product of the reaction. R. NH Он CH3 CH, -N- CH3 backbone

3. Some medications permanently inactivate their target enzyme by forming a covalent bond to an amino acid in the enzyme's active site. Aspirin is one example of a pharmaceutical that uses this type of mechanism. So is penicillin. As you saw in the last chapter, the active portion of penicillin is the B-lactam ring. Penicillin forms a covalent bond to serine in the active site of transpeptidase, an enzyme that is essential for forming the bacterial cell wall. Propose a mechanism for the inactivation of transpeptidase by penicillin and show the final product of the reaction. R. NH Он CH3 CH, -N- CH3 backbone

Introductory Chemistry: An Active Learning Approach

6th Edition

ISBN:9781305079250

Author:Mark S. Cracolice, Ed Peters

Publisher:Mark S. Cracolice, Ed Peters

Chapter22: Biochemistry

Section: Chapter Questions

Problem 22.3TC

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Similar questions

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. Describe the lock-and-key model for enzymes. Why are the shapes of the enzyme and its substrate important in this model? What does it mean to say that an enzyme is inhibited by a particular molecule? What happens if this inhibition is irreversible? Can you think of a situation in which it might be advantageous to be able to inhibit an enzyme?
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Write a brief description of the relationships among each of the following groups of terms or phrases. Answers to the Concept-Linking Exercises are given at the end of the chapter. Enzyme, enzyme substrate, active site, induced fit model