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5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose 6-phosphate CH₂0-P CH₂OH H HO H HO H OH ATP GLYCOLYSIS: Energy Investment Phase ADP Phospho- fructokinase Fructose 1,6-bisphosphate P-OCH, H HO H HO CH₂O-P кон H Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 CH₂0-P C-o CH₂OH Dihydroxyacetone phosphate (DHAP) ₁₁

5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose 6-phosphate CH₂0-P CH₂OH H HO H HO H OH ATP GLYCOLYSIS: Energy Investment Phase ADP Phospho- fructokinase Fructose 1,6-bisphosphate P-OCH, H HO H HO CH₂O-P кон H Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 CH₂0-P C-o CH₂OH Dihydroxyacetone phosphate (DHAP) ₁₁

Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter7: Cellular Respiration: Harvesting Chemical Energy
Section: Chapter Questions
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5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose ATP 6-phosphate CH₂0-P CH₂OH H H HO HO H OH GLYCOLYSIS: Energy Investment Phase Fructose 1,6-bisphosphate ADP P-OCH ₂ Phospho- fructokinase 3 H HO H HO H CH₂O-P OH Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 Dihydroxyacetone phosphate (DHAP) CH₂0-P C=O CH₂OH
Transcribed Image Text:5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose ATP 6-phosphate CH₂0-P CH₂OH H H HO HO H OH GLYCOLYSIS: Energy Investment Phase Fructose 1,6-bisphosphate ADP P-OCH ₂ Phospho- fructokinase 3 H HO H HO H CH₂O-P OH Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 Dihydroxyacetone phosphate (DHAP) CH₂0-P C=O CH₂OH
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