5.Draw the pedigree you constructed on the whiteboard for Exercise III.6. Assuming no crossing over occurs between the Huntington gene and the SNP marker, will Velmadevelop Huntington Disease? Will her younger brother develop Huntington Disease?7. Assuming no crossing over occurs between the Huntington gene and the SNP marker, what isthe chance that Velma will pass the Huntington Disease gene to her progeny if her husband doesnot carry the disease gene? Exercise Ill:For this lab exercise, you will evaluate a human pedigree for a particular disease, Huntington disease.Huntington disease is a progressive neurodegenerative disorder that is inherited in an autosomaldominant pattern. The disease presents around the age of 40, although there are juvenile onsetforms of the disease. Suppose that there is a SNP closely linked to the Huntington gene, so close thatthere is little crossing over between the SNP and the Huntington gene.Consider the following family:Velma's father, now deceased, had Huntington Disease, but neither of his parents had the disease;therefore, it was a new mutation that caused his disease. Velma's mother does not have the disease.Before his death, Velma's father was genotyped for the SNP marker that is linked to the Huntingtongene, and it was determined that he has alleles A1 and A2. Velma's mother was also genotyped andhas alleles A1 and A3. Velma has one brother (age 45) who has Huntington Disease, and genotypingof this brother revealed he has two copies of the A1 SNP allele. Velma has another brother (age 35)who currently does not have symptoms of the disease, and has SNP alleles A1 and A2. At the ageof 37, Velma does not currently have symptoms of the disease, and genotyping of her SNP markerrevealed that she has alleles A1 and A3.1. Using your whiteboard, construct a pedigree for this family, using filled-in symbols to reflectthose with Huntington disease. Under each symbol, write the genotype of Velma, her parents,and her brothers to reflect both the Huntington gene and the SNP marker. Assume that nocrossing over takes place between the gene and the marker. Transfer your pedigree and thegenotypes to #5 on the Data Sheet.Hint: to write the genotypes, be sure to illustrate the linkage between the Huntington gene andthe SNP marker so that you can visualize what is on each chromosome. For example, an individualwithout Huntington Disease with SNP alleles A2 and A3 would be written as:h A2h A32. Based on the pedigree you constructed, answer questions 6-8 on the Data Sheet.

Answered: Image /qna-images/answer/391cefc4-440b-4e75-8c7f-70ad812ee188.jpg

6. Assuming no crossing over occurs between the Huntington gene and th develop Huntington Disease? Will her younger brother develop Huntin 7. Assuming no crossing over occurs between the Huntington gene and th the chance that Velma will pass the Huntington Disease gene to her pro not carry the disease gene?

6. Assuming no crossing over occurs between the Huntington gene and th develop Huntington Disease? Will her younger brother develop Huntin 7. Assuming no crossing over occurs between the Huntington gene and th the chance that Velma will pass the Huntington Disease gene to her pro not carry the disease gene?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations

Section: Chapter Questions

Problem 1CS: Genetics in Practice case studies are critical-thinking exercises that allow you to apply your new...

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