A clinical test sometimes used to diagnose folate deficiency or B12 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of biochemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why?

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter10: From Proteins To Phenotypes
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Problem 16QP: The normal enzyme required for converting sugars into glucose is present in cells, but the...
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A clinical test sometimes used to diagnose folate deficiency or B12 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of biochemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why?

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