A dinical test sometimes used to diagnose folate deficiency or B,2 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of biochemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why?

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter25: Nitrogen Acquisition And Amino Acid Metabolism
Section: Chapter Questions
Problem 20P: Consider the synthesis and degradation of tyrosine as shown in Figures 25.37, 25.38, and 25.48 to...
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A dinical test sometimes used to diagnose folate deficiency or B,2 deficiency
is a histidine tolerance test, where one injects a large dose of histidine into
the bloodstream and then carries out a series of biochemical determinations.
What histidine metabolite would you expect to accumulate in a folate- or
B12-deficient patient, and why?
Transcribed Image Text:A dinical test sometimes used to diagnose folate deficiency or B,2 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of biochemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why?
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