A particular tumor cell has a mutation that makes MAPKKK hyperactive, leading to constitutive cell signaling for proliferation. Listed below are targets inhibited by specific drugs. Which drug would block cell signaling in this tumor? None of the options are correct A drug targeting the receptor-kinase All of the options are correct A drug targeting MAPK A drug targeting Ras

A particular tumor cell has a mutation that makes MAPKKK hyperactive, leading to constitutive cell signaling for proliferation. Listed below are targets inhibited by specific drugs. Which drug would block cell signaling in this tumor? None of the options are correct A drug targeting the receptor-kinase All of the options are correct A drug targeting MAPK A drug targeting Ras

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter9: Cell Communication

Section: Chapter Questions

Problem 8TYK

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Calcium ions (a) can act as second messengers (b) split calmodulin (c) are kept at higher concentration in the cytosol than in the extracellular fluid (d) are produced in the ER by protein kinases and protein phosphatases (e) typically terminate signaling cascades
Protein phosphorylation is commonly involved with all of thefollowing except(A) activation of receptor tyrosine kinases.(B) activation of protein kinase molecules.(C) activation of G protein-coupled receptors.(D) regulation of transcription by signaling molecules.
G proteins are involved wheneverA. Binding of messenger molecules to cell surface receptors triggers a target cell response.B. Binding of ligand molecules to cell surface receptors triggers activation or inhibition of enzymes,C. Binding of ligand molecules to cell surface receptors triggers synthesis of second messengers,D. Binding of ligand molecules to cell surface receptors triggers a change.E. All of the above.
All cells of a multicellular organism may not respond in the same wayto a particular ligand (signaling molecule) that binds to a cell surfacereceptor. The difference in response may be due toa. the type of receptor for the ligand that the cell expresses.b the affinity of the ligand for the receptor in a given cell type.c. the type of signal transduction pathways that the cell expresses.d. the type of target proteins that the cell expresses.e. all of the above.
a universal feature of cell signaling receptors is that they? a. undergo a structural (shape) change when the signal molecule is bound b. are present only in the plasma membrane c. are only ion channels d. are protein kinases e. aer only nuclear receptors
In the RAD signaling pathway the EGF ligand binds the EGF receptor, this initiated a phosphorylation cascade that results in cell proliferation. Which of the following statements is correct: a. RAS protein is the sognal b. EGF ligand is the signal c. cell proliferation is the signal d. EGF receptor is the signal e. none of the above
What type of cell signaling receptor is depicted below a. Cytoplasmic Receptor b. Transmembrane Receptor c. Intracellular Receptor d. Nuclear Receptor
Which of the following are regulators of Cdks? Choose all that apply. There are 3 correct answers. You will LOSE points (from the total correct) for incorrect answers. This is to discourage guessing. licensing proteins activating kinases cyclins inhibiting kinases Rb Mad and Bub proteins
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In an infected breast tissue, which of the following will not be consistent with the pathway of apoptosis in the tissue? Group of answer choices Toll-like receptors are activated by the invading organism RIPk1 binds to FADD causing Caspase 9 activation BID translocates to the mitochondria to promote MOMP XIAP is inhibited by Smac
This inhibatory kinase phosphorylates an inactive M-Cdk. a) M-kinase b) Wee1 c) CAK d) Cdc25
In this mechanim of receptor regulation, there is uncoupling of the signaling pathway. Even though the ligand is bound to the receptor located in the plasma membrane, downstream signaling is not occuring. This is best described as: Answers A-D A receptor internalization B receptor desensitization C receptor sensitization 5 D receptor downregulation