A growth factor Fsh3 stimulates the proliferation of culture fish cells. The receptorthat binds Fsh3 is a receptor tyrosine kinase (RTK) and there are numerous fishtumor cell lines that have a mutation for the gen for this receptor. Which of thefollowing mutations would be expected to promote uncontrolled cell proliferation.a mutation that inactivates the protein tyrosine phosphatase that acts on thereceptora mutation that prevents the binding of the normal extracellular signal to thereceptora mutation that inhibits the Ras GEFa mutation that destroys the kinase activity of the receptora mutation that prevents dimerization of the receptor

Answer. Enzyme-linked receptors are a second major type of cell surface receptors. Like…

that binds Fsh3 is a receptor tyrosine kinase (RTK) and there are numerous fish tumor cell lines that have a mutation for the gen for this receptor. Which of the following mutations would be expected to promote uncontrolled cell proliferation.

that binds Fsh3 is a receptor tyrosine kinase (RTK) and there are numerous fish tumor cell lines that have a mutation for the gen for this receptor. Which of the following mutations would be expected to promote uncontrolled cell proliferation.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.

Question

A growth factor Fsh3 stimulates the proliferation of culture fish cells. The receptor
that binds Fsh3 is a receptor tyrosine kinase (RTK) and there are numerous fish
tumor cell lines that have a mutation for the gen for this receptor. Which of the
following mutations would be expected to promote uncontrolled cell proliferation.
a mutation that inactivates the protein tyrosine phosphatase that acts on the
receptor
a mutation that prevents the binding of the normal extracellular signal to the
receptor
a mutation that inhibits the Ras GEF
a mutation that destroys the kinase activity of the receptor
a mutation that prevents dimerization of the receptor

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