A-protein complex concentration of 1.00×10−6M, and the drug B solution has a B-protein complex concentration of 1.40×10−6M.

Principles of Modern Chemistry
8th Edition
ISBN:9781305079113
Author:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Chapter14: Chemical Equilibrium
Section: Chapter Questions
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A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.86×10−6 M . Drug A is introduced into the protein solution at an initial concentration of 2.00×10−6M. Drug B is introduced into a separate, identical protein solution at an initial concentration of 2.00×10−6M. At equilibrium, the drug A-protein solution has an A-protein complex concentration of 1.00×10−6M, and the drug B solution has a B-protein complex concentration of 1.40×10−6M.

 

 

 

A. Calculate the Kc value for the A-protein binding reaction. (Express your answer using two significant figures.)

 

B. Calculate the Kc value for the B-protein binding reaction. (Express your answer using two significant figures.)

 

C. Assuming that the drug that binds more strongly will be more effective, which drug is the better choice for further research?

A. Drug B is the better choice for further research.
B. Drug A is the better choice for further research.
 
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