An enzyme is mutated such that the KM of the mutated enzyme is lower than the KM of the original enzyme. Which of the following statements is true (select all correct answers)?   Question 2 options:     If the original enzyme and the mutated enzyme are mixed with the same concentration of substrate, the mutated enzyme will have v0 closer to Vmax (hint: consider the Michaelis-Menten equation)     The effect of a particular competitive inhibitor will be less on the mutated enzyme than it is on the original enzyme (hint: consider the reaction scheme for a competitive inhibitor)     The effect of a particular uncompetitive inhibitor will be less on the mutated enzyme than it is on the original enzyme (hint: consider the reaction scheme for an uncompetitive inhibitor)     The mutated enzyme has higher affinity for the substrate than the original enzyme does

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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An enzyme is mutated such that the KM of the mutated enzyme is lower than the KM of the original enzyme. Which of the following statements is true (select all correct answers)?

 

Question 2 options:

 

 

If the original enzyme and the mutated enzyme are mixed with the same concentration of substrate, the mutated enzyme will have v0 closer to Vmax (hint: consider the Michaelis-Menten equation)

 

 

The effect of a particular competitive inhibitor will be less on the mutated enzyme than it is on the original enzyme (hint: consider the reaction scheme for a competitive inhibitor)

 

 

The effect of a particular uncompetitive inhibitor will be less on the mutated enzyme than it is on the original enzyme (hint: consider the reaction scheme for an uncompetitive inhibitor)

 

 

The mutated enzyme has higher affinity for the substrate than the original enzyme does

 

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