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ASSAY - 20 tablets weighing 2.58 g were crushed to a powder. A portion of the crushed powder (0.5283 g) was shaken with 50 mL of 0.1 M HCI, the mixture was filtered and made up to 100 mL. 10 ml of this solution was further diluted to 100 mL with 0.1 M HCI. The measured absorbance of the diluted solution at 276 nm was 0.582. Additional information: A196 = 72.3, stated content = 20 mg Calculate:

ASSAY - 20 tablets weighing 2.58 g were crushed to a powder. A portion of the crushed powder (0.5283 g) was shaken with 50 mL of 0.1 M HCI, the mixture was filtered and made up to 100 mL. 10 ml of this solution was further diluted to 100 mL with 0.1 M HCI. The measured absorbance of the diluted solution at 276 nm was 0.582. Additional information: A196 = 72.3, stated content = 20 mg Calculate:

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Orciprenaline (C11H17NO3, 211.258 g/mol) is a bronchodilator used in the treatment of asthma. The BP assay for orciprenaline tablets is described below. Read the following information carefully and answer the questions below. (Record your answers in decimal notation to the indicated significant figures OR decimal places) ASSAY - 20 tablets weighing 2.58 g were crushed to a powder. A portion of the crushed powder (0.5283 g) was shaken with 50 mL of 0.1 M HCI, the mixture was filtered and made up to 100 mL. 10 mL of this solution was further diluted to 100 mL with 0.1 M HCI. The measured absorbance of the diluted solution at 276 nm was 0.582. Additional information: A19 = 72.3, stated content = 20 mg Calculate: a) The concentration of orciprenaline in the diluted solution in mg/L Answer = mg/L (2 decimal places) b) The actual amount of orciprenaline (in mg) in the powder assayed. Answer = mg (1 decimal place) C) The actual amount of orciprenaline (in mg) per tablet. Answer = mg (1 decimal place) d) The percentage of stated content of per tablet. Answer = % (1 decimal places)
Transcribed Image Text:Orciprenaline (C11H17NO3, 211.258 g/mol) is a bronchodilator used in the treatment of asthma. The BP assay for orciprenaline tablets is described below. Read the following information carefully and answer the questions below. (Record your answers in decimal notation to the indicated significant figures OR decimal places) ASSAY - 20 tablets weighing 2.58 g were crushed to a powder. A portion of the crushed powder (0.5283 g) was shaken with 50 mL of 0.1 M HCI, the mixture was filtered and made up to 100 mL. 10 mL of this solution was further diluted to 100 mL with 0.1 M HCI. The measured absorbance of the diluted solution at 276 nm was 0.582. Additional information: A19 = 72.3, stated content = 20 mg Calculate: a) The concentration of orciprenaline in the diluted solution in mg/L Answer = mg/L (2 decimal places) b) The actual amount of orciprenaline (in mg) in the powder assayed. Answer = mg (1 decimal place) C) The actual amount of orciprenaline (in mg) per tablet. Answer = mg (1 decimal place) d) The percentage of stated content of per tablet. Answer = % (1 decimal places)
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