At pI for the amino acid glycine, NH2CH2COOH, using the chemical formula of the molecule, please show how the charges (if any) would be distributed across the molecule? B) What would be the net charge on the molecule at the pH equal to glycine’s pI?

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Chapter22: Organic And Biological Molecules
Section: Chapter Questions
Problem 83E
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A) At pI for the amino acid glycine, NH2CH2COOH, using the chemical formula of the molecule, please show how the charges (if any) would be distributed across the molecule? B) What would be the net charge on the molecule at the pH equal to glycine’s pI?
Expert Solution
Overview
  • The pI (isoelectric point) of an amino acid refers to the pH at which the amino acid has a net zero charge.
  • At this pH, the number of positively charged amino groups (NH3+) is equal to the number of negatively charged carboxyl groups (COO-).
  • The pI of an amino acid can vary depending on the type of amino acid, but typically ranges between 4.5-9.5.
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