please help me with this problem Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for both Kinase A and CDKI. CDKİ is a cell cycle inhibitor, and phosphorylation of CDKI by Kinase A willinhibit the normal function of CDKİ, as diagrammed below.Wild type Kinase A activates mitosisWild type CDKİ inactivates mitosisWild type Kinase A can inactivate CDKIH= InhibitsCDKIKinase AMitosisG1G2S-phase B) If a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of function)? Explain.

There are two types of functional mutations. 1) gain of function mutations 2) loss of function…

Answered: B) If a tumor-promoting mutation in the…

B) If a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of function)? Explain.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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please help me with this problem

Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for both Kinase A and CDKI. CDKİ is a cell cycle inhibitor, and phosphorylation of CDKI by Kinase A will
inhibit the normal function of CDKİ, as diagrammed below.
Wild type Kinase A activates mitosis
Wild type CDKİ inactivates mitosis
Wild type Kinase A can inactivate CDKI
H= Inhibits
CDKI
Kinase A
Mitosis
G1
G2
S-phase

B) If a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of function)? Explain.

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