Between direct and indirect allosteric kinase inhibitors, which do you think requires a larger conformational change in response to binding of the allosteric modulator? Why?
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Between direct and indirect allosteric kinase inhibitors, which do you think requires a larger conformational change in response to binding of the allosteric modulator? Why?
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- What would be the effect of inhibiting the kinase?What are the primary structures of the 1AWJ tyrosine kinase enzyme? What are the secondary structures of the 1AWJ tyrosine kinase enzyme? What is the property of tyrosine kinase enzymes?Cyclic adenosine monophosphate (CAMP) is a molecule that can act as anallosteric activator of kinase enzymes inside of the cytoplasm. Describehow CAMP molecules affect kinase enzymes?
- Protein Kinase A can phosphorylate different proteins in different cells. Explain the role of AKAP’s (A Kinase Anchoring Protein’s) in determining which substrates of Protein Kinase A will get phosphorylated in particular cells.Does adenylate cyclase become more active when the inhibitory (Gia) protein is mutated and increases its intrinsic GTPase activity?Continuous exposure of a G protein-coupled receptor to its ligand leads to a phenomenon known as desensitization. Describe several molecule mechanisms for receptor desensitization
- Explain, in detail, how tyrosine kinase proteins are involved in one signal transduction pathway of your choice. Make sure you describe the complete pathway in which it is involved. Then, describe how you would experimentally demonstrate the requirement of a tyrosine kinase protein in your chosen pathway.If you have a protein kinase that is regulated by both small molecule inhibitors as well as by phosphorylation, and is part of a cooperative enzyme complex that works as part of a larger pathway involving kinase and GTPase proteins please explain where on this protein regulation could occur, how different types of inhibition could control the function of the protein as well as the function of the complex, and how the protein could regulate other proteins. (This question was previously answered but it was answered incompletely mentioning an herbicide developed in the 1950's. Apparently, it was a plagiarized excerpt from an NCBI article. This is a repost for a full and complete answer. Thank you so much for your help! :) )What is the function of a protein kinase? What amino acids are often phosphorylated by kinases?