- Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. mTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk ippo thway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway 3. The activated Akt, a serine threonine kinase, inhibits the TSC1-TSC2 complex, allowing Rheb to activate mTORC1. Mst РІЗК PTEN Lats AKT 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- Ragulator complex. miR-29 YAP TSC2-TSC1 amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in turn downregulates PTEN, an inhibitor of PI(3)K and Akt. So, the two pathways crosstalk and cell growth Created in BioRender.com coordinate cell number and growth. c) Which protein possesses this enzymatic activity within that pathway?
- Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. mTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk ippo thway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway 3. The activated Akt, a serine threonine kinase, inhibits the TSC1-TSC2 complex, allowing Rheb to activate mTORC1. Mst РІЗК PTEN Lats AKT 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- Ragulator complex. miR-29 YAP TSC2-TSC1 amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in turn downregulates PTEN, an inhibitor of PI(3)K and Akt. So, the two pathways crosstalk and cell growth Created in BioRender.com coordinate cell number and growth. c) Which protein possesses this enzymatic activity within that pathway?
Comprehensive Medical Assisting: Administrative and Clinical Competencies (MindTap Course List)
6th Edition
ISBN:9781305964792
Author:Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Publisher:Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Chapter15: Medical Documents
Section: Chapter Questions
Problem 15.1CS
Related questions
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Comprehensive Medical Assisting: Administrative a…
Nursing
ISBN:
9781305964792
Author:
Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Publisher:
Cengage Learning
Comprehensive Medical Assisting: Administrative a…
Nursing
ISBN:
9781305964792
Author:
Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Publisher:
Cengage Learning