Besides better aeration and mixing properties, what other advantages do stirred tank bioreactors have over shake flasks?

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Chapter7: Preventing Perioperative Disease Transmission
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Besides better aeration and mixing properties, what other advantages do stirred tank bioreactors have over shake flasks?

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A bioreactor is a man-made device specially designed for supporting biologically active environment. It can be used for carrying out various chemical processes that involves biochemically active micro-organisms.

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