Linked functions A protein exists in a conformational equilibrium between a T conformation and an R conformation. See the linked functions diagram below showing H+ dissociation from a functional group on the protein in the T conformation and the same group on the protein in the R conformation. The proton equilibrium dissociation constant depends on which conformation (T or R) the protein is in. KTR T•H* R•H* Suppose that KTH+ = 2 x 10-7 M KTH KRH* KRH+ = 4 x 10-6 M %3D KIR K'TR = 5 x 10-3 %3D T+H* R+ H* Note: The reactions are proceeding from the upper left to lower right. KTR = Equilibrium constant for T•H* -> R•H* = The [R•H*]/ [T•H*] ratio with the group protonated. K'TR = Equilibrium constant for T-> R = The [R]/[T]ratio with the group protonated. KTH+ = Equilibrium dissociation constant for proton dissociation from the T conformation. KRH+ = Equilibrium dissociation constant for proton dissociation from the R conformation. The pK, value of the group on the protein in the T state is Type your answer...

Linked functions A protein exists in a conformational equilibrium between a T conformation and an R conformation. See the linked functions diagram below showing H+ dissociation from a functional group on the protein in the T conformation and the same group on the protein in the R conformation. The proton equilibrium dissociation constant depends on which conformation (T or R) the protein is in. KTR T•H* R•H* Suppose that KTH+ = 2 x 10-7 M KTH KRH* KRH+ = 4 x 10-6 M %3D KIR K'TR = 5 x 10-3 %3D T+H* R+ H* Note: The reactions are proceeding from the upper left to lower right. KTR = Equilibrium constant for T•H* -> R•H* = The [R•H]/ [T•H] ratio with the group protonated. K'TR = Equilibrium constant for T-> R = The [R]/[T]ratio with the group protonated. KTH+ = Equilibrium dissociation constant for proton dissociation from the T conformation. KRH+ = Equilibrium dissociation constant for proton dissociation from the R conformation. The pK, value of the group on the protein in the T state is Type your answer...

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter31: Completing The Protein Life Cycle: Folding, Processing, And Degradation

Section: Chapter Questions

Problem 3P: Understanding the Relevance of Chaperones in Protein Folding Protein molecules, like all molecules,...

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