A. Write the structure of the following peptide at pH 5.0 and calculate its net charge at this pH. Asp-His-Tyr-Arg-Lys-Leu-Thr-Gln. Based on the pKa value of the ionizable groups.

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Chapter1: Biochemistry: An Evolving Science
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A. Write the structure of the following peptide at pH 5.0 and calculate its net charge at this pH.

Asp-His-Tyr-Arg-Lys-Leu-Thr-Gln. Based on the pKa value of the ionizable groups.

 

B. A polypeptide consisting only of L-glutamate residues (poly-L-glutamate) may have a random coil or helical structure depending on pH.

Explain this behavior by indicating at what pH values the helical structure will be favored.

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