Phosphoglycerate mutase mechanism is shown below: Phosphoglycerate mutase His His 2-0,pN+ "ooc H-C-0-PO N: H+ H,c-0-PO 3-Phosphoglycerate 2,3-Bisphosphoglycerate (2,3-BPG) HN HN His His His His 2-0,P-N* H-C-0-PO; -ooc H-C-0-PO H,C-0-Po 2,3-Bisphosphoglycerate N+ H,C-0-H (2,3-BPG) HN 2-Phosphoglycerate HN -His -His A) What is the role of P on His in step 1? [Select] B) What is the role of the ring nitrogen (with the lone pair shown) of the nonphosphorylated His residue in step 1? [ Select ] C) What is the electrophile in step 2. [ Select] D) What is the role of NH* of the lower His residue in step 2? general base

Phosphoglycerate mutase mechanism is shown below: Phosphoglycerate mutase His His 2-0,pN+ "ooc H-C-0-PO N: H+ H,c-0-PO 3-Phosphoglycerate 2,3-Bisphosphoglycerate (2,3-BPG) HN HN His His His His 2-0,P-N* H-C-0-PO; -ooc H-C-0-PO H,C-0-Po 2,3-Bisphosphoglycerate N+ H,C-0-H (2,3-BPG) HN 2-Phosphoglycerate HN -His -His A) What is the role of P on His in step 1? [Select] B) What is the role of the ring nitrogen (with the lone pair shown) of the nonphosphorylated His residue in step 1? [ Select ] C) What is the electrophile in step 2. [ Select] D) What is the role of NH* of the lower His residue in step 2? general base

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 40MP: The hydrolysis of a biological thioester to the corresponding carboxyl-ate is often more complex...

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