Calculate the matching probability (pM) and the power of discrimination (PD) for a gene with two alleles (A1 and A2), where the frequency of A1 = 0.8 (assume equilibrium conditions apply). Is this a good marker for forensic analysis?
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- For most cases, a p value of 0.05 is used to determine whether results fit expected values. Is this a magic number, or could p values be set more stringently, say 0.01, or more lax, say 0.10? What effect would these values have on the reliability of the chi-square test?Explain the multiple testing problem of GWAS - why do we need such a small p-value to achieve significance?Explain the similarities and differences between the procedures used for the coarse-scale mapping and finescale mapping of QTLs through controlled crosses, as was accomplished for QTLs involved with tomato size.
- How to find any evidence of cantamination or degradation of DNA in the DNA profiles you examined? how important is the detabase that is used to determine allele frequencies in DNA profiling cases(a) Explain sensitivity and selectivity in terms of true and false positives. (b) What is the advantage of a Needleman-Wunsch alignment compared to a seeded alignment? (c) What does the expectation parameter mean in local alignment? What will happen if the expectation value is increased from its default value of 10 to a 100?How are the standard deviation and variance related to each other? How are they different than just measuring the range? Can plot samples of dandelion cover from two different locations have the same mean but different variance? Explain. Can you answer question 3? Thanks.
- Which of the following would NOT be characteristic of a single-source non-compromised STR profile? Group of answer choices A. No more than two (2) allelic peaks at any locus. B. Well-balanced heterozygote peaks. C. Sharply pointed peaks with even spectral distribution D. Well-defined smooth peaks with a bell-shaped distribution.Using the product rule, what is the total frequency of the profile, given the following genotype frequencies for each of the loci: D3S1358 = 0.04453 vWA = 0.02725 D5S818 = 0.07534 0.008406 0.0000914 0.14712 10,491 0.914208importance of sample size in studies involving probabilities
- After doing PCR in several labs, 29 homozygous large, 62 heterozygotes, and 9 homozygous small bands were obtained. What is the frequency of the small alleleIf interference is complete (i.e., 100% effective), what is the frequency of double crossovers one should expect? Enter a number rounded to two decimal places.If, for an observed data set, a specified gene, and two phenotype classes (disease and wild type), then the number of degrees of freedom for the chi-square goodness of fit test when studying the F2 generation is: a) 0 b) 3 c) -1 d) 2 e) 1