Huntington disease (HD) is a rare dominant condition in humans that results in a slow but inexorable deterioration of the nervous system. HD shows what might be called “age-dependent penetrance,” which is to say that the probability that a person with the HD genotype will express the phenotype varies with age. Assume that 50% of those inheriting the HD allele will express the symptoms by age 40. Susan is a 35-year-old woman whose father has HD. She currently shows no symptoms. What is the probability that Susan will show symptoms in five years?

Huntington disease (HD) is a rare dominant condition in humans that results in a slow but inexorable deterioration of the nervous system. HD shows what might be called “age-dependent penetrance,” which is to say that the probability that a person with the HD genotype will express the phenotype varies with age. Assume that 50% of those inheriting the HD allele will express the symptoms by age 40. Susan is a 35-year-old woman whose father has HD. She currently shows no symptoms. What is the probability that Susan will show symptoms in five years?

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Description: Huntington disease (HD) is a rare dominant condition in humans that results in a slow but inexorable deterioration of the nervous system. HD shows what might be called “age-dependent penetrance,” which is to say that the probability that a person wit

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter5: The Inheritance Of Complex Traits

Section: Chapter Questions

Problem 5QP: As it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women....

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Huntington disease is a rare dominant condition in humans that results in a slow but inexorable deteriorationof the nervous system. The disease shows what mightbe called age-dependent penetrance, which is to saythat the probability that a person with the Huntingtongenotype will express the phenotype varies with age.Assume that 50% of those inheriting the HD allele willexpress the symptoms by age 40. Susan is a 35-yearold woman whose father has Huntington disease. Shecurrently shows no symptoms. What is the probabilitythat Susan will show symptoms in five years?