Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Question: A drug that has been screened in cancer model through the generation of induced pluripotent stem cells. Please explain in detail the main findings

Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Question: A drug that has been screened in cancer model through the generation of induced pluripotent stem cells. Please explain in detail the main findings

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section12.10: Genomics, Epigenetics,and Cancer

Problem 2GR: Another model, the random model, proposes that any cell in a malignant tumor has the potential to...

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Some cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying this insensitivity uncovered an ability by these cells to pump the treatment drug out of the cell against its concentration gradient. Additional drugs have been developed that inhibit the pump, thus trapping the chemotherapeutic agent inside to promote cancer cell destruction. The Figure shows what happens when two types of cells are treated with a 3H-labeled anti-cancer drug, paclitaxel. Which set of cells (A or B) would be described as resistant to the cancer treatment? Explain your answer. What type of transport are the resistant cells using?
Some cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying this insensitivity uncovered an ability by these cells to pump the treatment drug out of the cell against its concentration gradient. Additional drugs have been developed that inhibit the pump, thus trapping the chemotherapeutic agent inside to promote cancer cell destruction. The Figure shows what happens when two types of cells are treated with a 3H-labeled anti-cancer drug, paclitaxel. Two additional drugs, imatinib and nilotinib, are evaluated for their ability to overcome the cancer cells ability to pump out the chemotherapeutic agent. An asterisk (*) indicates a statistically significant difference from the cells receiving paclitaxel alone. Do the additional drugs seem to the effective in over-coming the pump? Which set of graphs (A or B) best supports your answer? Explain your answer.
Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Please select a disease (like cancer) that can be modeled through the generation of induced pluripotent stem cells. You can use published literature and explain:1) why is it important to model such a disease?2) what were the key findings after modeling such a disease? 3) a drug that has been screened in this disease model. Explain in detail the main findings.
A drug that has been screened in cancer model through the generation of induced pluripotent stem cells. Explain in detail the main findings.
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Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please explain in details
Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Please select a disease that can be modeled through the generation of induced pluripotent stem cells. What were the key findings after modeling such a disease? Please explain clearly with example Thank you
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